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Interferon-gamma (IFNγ) exerts diverse responses in B cell development ranging from growth arrest and apoptosis to proliferation and differentiation. IFNγ stimulates murine 70Z/3 pre-B cells to express surface immunoglobulin (Ig) and this system serves as a useful model for the pre-B to immature B cell transition in B cell development. To analyze this developmental transition, we used a PCR-based...
The mb-1 (Igα) gene is B cell-specific and expressed throughout B cell maturation. In combination with B29 (Igβ) and surface immunoglobulin mb-1 comprises the B cell receptor complex (BCR). The murine mb-1 promoter has been characterized to depend on the trans-acting transcription factors; Sp1, ets, lkaros, and EBF for full promoter activity. These trans-acting factors are also involved in the regulation...
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