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This paper presents a compact analytical model for the AC response of nanoelectrode-based impedimetric biosensors to dielectric nanoparticles suspended in the electrolyte. The model highlights the functional dependence of the impedance change on the nanoparticle and the system geometrical and physical parameters. The model is carefully verified by means of 2-D simulations carried out with an ad hoc...
We describe a technique to overcome the numerical difficulties in the accurate description of the small signal AC response of the thin electrical double layers at the surface of impedimetric biosensor electrodes. The technique significantly reduces the computational burden of the calculation, thus enabling the fast simulation of many analyte configurations.
This paper investigates the response of a nanoelectrode based capacitive biosensor to the presence of single and double strands of DNA/PNA. The expected admittance spectrum for an idealized system with cylindrical symmetry, where the biomolecule is represented by a simple dielectric and charged rod, is calculated over a broad frequency range extending from below to above the electrolyte's dielectric...
This paper presents a case study of the interaction between nanoelectrodes and dielectric nanoparticles possibly representative of biomolecules in a simple cylindrical capacitive biosensor. The small signal admittance change due to the insertion of the biomolecule in the biosensor electrolyte is studied as a function of the position, aspect ratio and charge of the biomolecule and of the signal frequency...
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