Search results for: Graeme N. Smith

Items from 1 to 20 out of 44 results

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Assessing cardiovascular disease risk in women with a history of hypertensive disorders of pregnancy: A guidance paper for studies using administrative data

Amy Johnston, Graeme N. Smith, Peter Tanuseputro, Thais Coutinho, more

Paediatric and Perinatal Epidemiology > 38 > 3 > 254 - 267

Background Hypertensive disorders of pregnancy (HDP) are a major cause of maternal morbidity and mortality, and their association with increased cardiovascular disease (CVD) risk represents a major public health concern. However, assessing CVD risk in women with a history of these conditions presents unique challenges, especially when studies are carried out using routinely collected data. Objectives...

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Guidelines for the management of pregnant women with obesity: A systematic review

Alexandre Simon, Misty Pratt, Brian Hutton, Becky Skidmore, more

Obesity Reviews > 21 > 3 > n/a - n/a

Multiple clinical practice guidelines (CPGs) have been established for pregnant women with obesity. The quality and consistency of recommendations remain unknown. The objective of this study is to conduct a systematic review to synthesize and appraise evidence from CPGs, available worldwide, for pregnant women affected by obesity. An experienced information specialist performed a rigorous search of...

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The role of maternal homocysteine concentration in placenta-mediated complications: findings from the Ottawa and Kingston birth cohort

Shazia H. Chaudhry, Monica Taljaard, Amanda J. MacFarlane, Laura M. Gaudet, more

BMC Pregnancy and Childbirth > 2019 > 19 > 1 > 1-10

Background Homocysteine is an intermediate metabolite implicated in the risk of placenta-mediated complications, including preeclampsia, placental abruption, fetal growth restriction, and pregnancy loss. Large cohort and case-control studies have reported inconsistent associations between homocysteine and these complications. The purpose of this study was to investigate whether elevated maternal plasma...

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Care plans for women pregnant using assisted reproductive technologies: a systematic review

Maria P. Velez, Candyce Hamel, Brian Hutton, Laura Gaudet, more

Reproductive Health > 2019 > 16 > 1 > 1-19

Background Between 1 and 5% of children in industrialized countries are conceived through Assisted Reproductive Technologies (ART). As infertility and the use of ART may be associated with adverse perinatal outcomes, care plans specific to these pregnancies are needed. We conducted a systematic review to examine the existing care plans specific to women pregnant following Assisted Reproductive Technologies...

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Neurological function in children born to preeclamptic and hypertensive mothers – A systematic review

Ernesto A. Figueiró-Filho, Lauren E. Mak, James N. Reynolds, Patrick W. Stroman, more

Pregnancy Hypertension: An International Journal of Women's Cardiovascular... > 2017 > 10 > C > 1-6

Offspring whose mothers developed preeclampsia (PE-F1s) show developmental effects that are now being identified, such as cognitive, behavioural, and mood differences compared to offspring from non-complicated pregnancies. We hypothesize that the progressive angiokine dysregulation associated with development of preeclampsia (PE) reflects gene dysregulation in pre-implantation conceptuses, and manifests...

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Differences in growth of Canadian children compared to the WHO 2006 Child Growth Standards

Alison L. Park, Karen Tu, Joel G. Ray, the Canadian Curves Consortium, more

Paediatric and Perinatal Epidemiology > 31 > 5 > 452 - 462

Background To evaluate if there are departures from the WHO Child Growth Standards (WHO‐CGS) in postnatal growth of healthy ‘Canadian’ children in Ontario up to age 2 years, including by infant feeding and ethnicity. Methods We included data on 9964 healthy, singleton children born in Ontario, Canada. Smoothed weight, length and body mass index (BMI) percentile curves were generated using quantile...

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Pre-gravid Determinants of New onset Hypertension in Pregnancy–Results from a Pre-conception Cohort Study in China

Shi Wu Wen, Hongzhuan Tan, Ravi Retnakaran, Minxue Shen, more

Annals of Epidemiology > 2017 > 27 > 8 > 532-533

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Pre-gravid predictors of new onset hypertension in pregnancy − Results from a pre-conception cohort study in China

Shi Wu Wen, Hongzhuan Tan, Ravi Retnakaran, Minxue Shen, more

European Journal of Obstetrics & Gynecology and Reproductive Biology > 2017 > 214 > C > 140-144

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Maternal Circulating microRNAs and Pre-Eclampsia: Challenges for Diagnostic Potential

Malia S. Q. Murphy, Chandrakant Tayade, Graeme N. Smith

Molecular Diagnosis & Therapy > 2017 > 21 > 1 > 23-30

Pre-eclampsia (PE) is a common hypertensive disorder of pregnancy with a significant impact on maternal and neonatal mortality and morbidity. While the pathogenesis of PE has been well described, identification of a biomarker(s) with robust predictive utility in identifying women at the highest risk of developing the condition has yet to be identified. In the search for diagnostic markers, those that...

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Impact of preeclampsia on cognitive function in the offspring

Matthew T. Rätsep, Andrew F. Hickman, Brandon Maser, Jessica Pudwell, more

Behavioural Brain Research > 2016 > 302 > C > 175-181

Preeclampsia (PE) is a significant clinical disorder occurring in 3–5% of all human pregnancies. Offspring of PE pregnancies (PE-F1s) are reported to exhibit greater cognitive impairment than offspring from uncomplicated pregnancies. Previous studies of PE-F1 cognitive ability used tests with bias that do not assess specific cognitive domains. To improve cognitive impairment classification in PE-F1s...

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Thromboelastography Identifies Cyclic Haemostatic Variations in Healthy Women Using Oral Contraceptives

Erin K.I. Murray, Malia S.Q. Murphy, Graeme N. Smith, Wilma M. Hopman, more

Thrombosis Research > 2015 > 136 > 5 > 1022-1026

Using thromboelastography (TEG) and standard laboratory haemostatic tests we examined the influence of the menstrual cycle and monophasic oral contraceptive (OC) use on haemostasis in healthy women. Tests were performed on citrated whole-blood and plasma (respectively) collected from 33 healthy non-pregnant women (18 non-OC users and 15 OC users) during menses, the follicular phase and the luteal...

article

Evidence of inflammation and predisposition toward metabolic syndrome after pre-eclampsia

Malia S.Q. Murphy, Chandrakant Tayade, Graeme N. Smith

Pregnancy Hypertension: An International Journal of Women's Cardiovascular... > 2015 > 5 > 4 > 354-358

Pre-eclampsia (PE) is a hypertensive disorder of pregnancy characterized by exaggerated inflammatory and metabolic responses. Women with a history of PE are at increased risk of the metabolic syndrome (MetS) and cardiovascular disease although the pathophysiological underpinnings of this association remain unclear. This study aimed to compare levels of plasma immunoregulatory factors with the presence...

article

Creation of plastinated placentas as a novel teaching resource for medical education in obstetrics and gynaecology

Karalyn E. McRae, Gregory A.L. Davies, Ronald A. Easteal, Graeme N. Smith

Placenta > 2015 > 36 > 9 > 1045-1051

Knowledge of the gross anatomy of the placenta is fundamental in order to help identify potential complications during pregnancy. The placenta is difficult to study without a three-dimensional appreciation of its structure. The aim of this study was to develop a collection of plastinated placenta specimens and accompanying clinical educational materials to provide learning resources for placental...

article

The Maternal Health Clinic: Improving women’s cardiovascular health

Graeme N. Smith

Seminars in Perinatology > 2015 > 39 > 4 > 316-319

Women’s cardiovascular health is a national priority that should be addressed through improving cardiovascular awareness and prevention. Given the costs of treating cardiovascular disease and screening for it, novel and innovative ways to identify women who should undergo risk screening and intervention, including lifestyle modification, is critical to achieve this goal. Pregnancy is seen as a vascular...

article

Impact of placental growth factor on brain vascular development, cognition and behavior

Matthew T. Rätsep, Angelina Paolozza, Bruno Zavan, Vanessa R. Kay, more

Placenta > 2015 > 36 > 4 > 471-472

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A mixed methods evaluation of the maternal-newborn dashboard in Ontario: dashboard attributes, contextual factors, and facilitators and barriers to use: a study protocol

Sandra Dunn, Ann E. Sprague, Jeremy M. Grimshaw, Ian D. Graham, more

Implementation Science > 2015 > 11 > 1 > 1-11

Background There are wide variations in maternal-newborn care practices and outcomes across Ontario. To help institutions and care providers learn about their own performance, the Better Outcomes Registry & Network (BORN) Ontario has implemented an audit and feedback system, the Maternal-Newborn Dashboard (MND), for all hospitals providing maternal-newborn care. The dashboard provides (1) near...

article

The maternal health clinic: an initiative for cardiovascular risk identification in women with pregnancy-related complications

Maria C. Cusimano, Jessica Pudwell, Michelle Roddy, Chan-Kyung Jane Cho, more

American Journal of Obstetrics and Gynecology > 2014 > 210 > 5 > 438.e1-438.e9

Women who develop certain common pregnancy complications have a greater chance of developing cardiovascular disease (CVD) later in life. However, most health care providers do not provide postpartum cardiovascular risk counselling or follow-up. The Maternal Health Clinic was established to address this gap in care. It targets women at increased risk of CVD to inspire lifestyle changes, encourage long-term...

article

Plasma cotinine indicates an increased risk of preeclampsia in previous and passive smokers

Zhong-Cheng Luo, Pierre Julien, Shu-Qin Wei, Francois Audibert, more

American Journal of Obstetrics and Gynecology > 2014 > 210 > 3 > 232.e1-232.e5

Self-reported tobacco smoking in pregnancy has been consistently associated with a decreased risk of developing preeclampsia, but the evidence has been limited and inconsistent for previous and passive smokers. Misclassifications and inaccuracies of self-reported tobacco exposure may disguise the true relationship. This study aimed to assess the association of gestational hypertension and preeclampsia...

article

Postpartum alterations in circulating endothelial progenitor cells in women with a history of pre-eclampsia

Malia S.Q. Murphy, Richard C. Casselman, Graeme N. Smith

Pregnancy Hypertension: An International Journal of Women's Cardiovascular... > 2013 > 3 > 3 > 178-185

To characterize persistent postpartum maternal endothelial dysfunction following pre-eclampsia (PE) through the assessment of endothelial progenitor cells as markers of endothelial reparative capacity.Maternal circulating endothelial progenitor cells were measured at 2months and 6months postpartum in women who had recently experienced PE pregnancies (n=17). Normotensive controls (n=13) with uncomplicated...

article

Infant outcomes among pregnant women who used oseltamivir for treatment of influenza during the H1N1 epidemic

Hai-yan Xie, Abdool S. Yasseen, Ri-hua Xie, Deshayne B. Fell, more

American Journal of Obstetrics and Gynecology > 2013 > 208 > 4 > 293.e1-293.e7

This study was undertaken to examine the association between maternal oseltamivir treatment for influenza and infant outcomes during the 2009 HINI influenza pandemic. This was a retrospective cohort study using a population-based maternal newborn database including women who gave birth to a singleton infant in the Canadian province of Ontario from November 2009 through April 2010. Risks of small...

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INFONA - science communication portal

Search results for: Graeme N. Smith

Assessing cardiovascular disease risk in women with a history of hypertensive disorders of pregnancy: A guidance paper for studies using administrative data

Guidelines for the management of pregnant women with obesity: A systematic review

The role of maternal homocysteine concentration in placenta-mediated complications: findings from the Ottawa and Kingston birth cohort

Care plans for women pregnant using assisted reproductive technologies: a systematic review

Neurological function in children born to preeclamptic and hypertensive mothers – A systematic review

Differences in growth of Canadian children compared to the WHO 2006 Child Growth Standards

Pre-gravid Determinants of New onset Hypertension in Pregnancy–Results from a Pre-conception Cohort Study in China

Pre-gravid predictors of new onset hypertension in pregnancy − Results from a pre-conception cohort study in China

Maternal Circulating microRNAs and Pre-Eclampsia: Challenges for Diagnostic Potential

Impact of preeclampsia on cognitive function in the offspring

Thromboelastography Identifies Cyclic Haemostatic Variations in Healthy Women Using Oral Contraceptives

Evidence of inflammation and predisposition toward metabolic syndrome after pre-eclampsia

Creation of plastinated placentas as a novel teaching resource for medical education in obstetrics and gynaecology

The Maternal Health Clinic: Improving women’s cardiovascular health

Impact of placental growth factor on brain vascular development, cognition and behavior

A mixed methods evaluation of the maternal-newborn dashboard in Ontario: dashboard attributes, contextual factors, and facilitators and barriers to use: a study protocol

The maternal health clinic: an initiative for cardiovascular risk identification in women with pregnancy-related complications

Plasma cotinine indicates an increased risk of preeclampsia in previous and passive smokers

Postpartum alterations in circulating endothelial progenitor cells in women with a history of pre-eclampsia

Infant outcomes among pregnant women who used oseltamivir for treatment of influenza during the H1N1 epidemic

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