Search results for: Mónica De la Fuente

Items from 1 to 20 out of 50 results

article

Aging is accompanied by T‐cell stiffening and reduced interstitial migration through dysfunctional nuclear organization

Blanca González‐Bermúdez, Hikaru Kobayashi, Aldo Abarca‐Ortega, Miguel Córcoles‐Lucas, more

Age‐associated changes in T‐cell function play a central role in immunosenescence. The role of aging in the decreased T‐cell repertoire, primarily because of thymic involution, has been extensively studied. However, increasing evidence indicates that aging also modulates the mechanical properties of cells and the internal ordering of diverse cell components. Cellular functions are generally dictated...

article

Improvement of Redox State and Functions of Immune Cells as Well as of Behavioral Response in Aged Mice After Two-Week Supplementation of Fermented Milk with Probiotics

Caroline Hunsche, Julia Cruces, Mónica De la Fuente

Current Microbiology > 2019 > 76 > 11 > 1278-1289

The homeostatic systems, such as the nervous and immune systems, show deterioration in aging as a consequence of the age-related oxidative-inflammatory stress establishment. The supplementation with fermented milk containing probiotic bacteria could be a good nutritional strategy to improve homeostatic system functions in aged individuals through the modulation of their redox state. The aim of the...

article

High perceived stress in women is linked to oxidation, inflammation and immunosenescence

Irene Martínez de Toda, Lara Miguélez, León Siboni, Carmen Vida, more

Biogerontology > 2019 > 20 > 6 > 823-835

Chronic stress situations lead to an impairment of immune response and higher oxidative and inflammatory stress, which are important underlying mechanisms of the ageing process. However, given that the physiological stress response depends on the subjective appraisal of a given stressor, the aim of the study was to investigate the effect that different degrees of perceived stress have, regardless...

article

Social environment improves immune function and redox state in several organs from prematurely aging female mice and increases their lifespan

Antonio Garrido, Julia Cruces, Noemí Ceprián, Isabel Corpas, more

Biogerontology > 2019 > 20 > 1 > 49-69

Aging is associated with a chronic oxidative stress (increase of oxidants and decrease of antioxidants), which contributes to immunosenescence and therefore shorter longevity. Nevertheless, a positive social network has been related to the adequate maintenance of health and deceleration of aging. Adult prematurely aging mice (PAM) are characterized by their inadequate stress response to a T-maze,...

article

Protective effect of xanthohumol against age-related brain damage

Lisa Rancán, Sergio D. Paredes, Irene García, Pedro Muñoz, more

The Journal of Nutritional Biochemistry > 2017 > 49 > C > 133-140

It has been recently shown that xanthohumol, a flavonoid present in hops, possesses antioxidant, anti-inflammatory and chemopreventive properties. However, its role in the aging brain has not been addressed so far. Therefore, this study aimed to investigate the possible neuroprotective activity of xanthohumol against age-related inflammatory and apoptotic brain damage in male senescence-accelerated...

article

Administration of a leptin antagonist during the neonatal leptin surge induces alterations in the redox and inflammatory state in peripubertal /adolescent rats

Virginia Mela, Oskarina Hernandez, Caroline Hunsche, Francisca Diaz, more

Molecular and Cellular Endocrinology > 2017 > 454 > C > 125-134

The importance of the neonatal leptin surge in rodents in neurodevelopmental processes has aroused curiosity in its implication in other physiological systems. Given the role of leptin in neuro-immune interactions, we hypothesized that the neonatal leptin surge could have an effect on the oxidative and inflammatory stress situations of both systems. We blocked the neonatal leptin surge by a leptin...

article

Parathyroid Hormone‐Related Protein Protects Osteoblastic Cells From Oxidative Stress by Activation of MKP1 Phosphatase

Juan A. Ardura, Sergio Portal‐Núñez, Irantzu Castelbón‐Calvo, Irene Martínez de Toda, more

Journal of Cellular Physiology > 232 > 4 > 785 - 796

Oxidative damage is an important contributor to the morphological and functional changes in osteoporotic bone. Aging increases the levels of reactive oxygen species (ROS) that cause oxidative stress and induce osteoblast apoptosis. ROS modify several signaling responses, including mitogen‐activated protein kinase (MAPK) activation, related to cell survival. Both parathyroid hormone (PTH) and its...

article

Hsp70 basal levels, a tissue marker of the rate of aging and longevity in mice

Irene Martínez de Toda, Carmen Vida, Eduardo Ortega, Mónica De La Fuente

Experimental Gerontology > 2016 > 84 > C > 21-28

Under stressful conditions, the expression of the chaperone Hsp70 is induced, which acts as a cellular defense mechanism. The impairment in this induction has been related to aging, whereas an increased expression has been related to longevity. Nevertheless, it is still not known if the basal levels of Hsp70 can be indicative of the aging rate of different tissues. The aim of this study was to quantify...

article

The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence

Moisés Evandro Bauer, Mónica De la Fuente

Mechanisms of Ageing and Development > 2016 > 158 > C > 27-37

Immunosenescence involves age-related remodeling changes in the organization of lymphoid organs and functionality of immune cells, which have been associated with increased morbidity and mortality The pace of immunosenescence is modulated, however, by both intrinsic and extrinsic factors. Here, we review the mechanisms by which some factors, like the oxidative stress and certain chronic viral infections,...

article

A higher anxiety state in old rats after social isolation is associated to an impairment of the immune response

Julia Cruces, César Venero, Inmaculada Pereda-Pérez, Mónica De la Fuente

Journal of Neuroimmunology > 2014 > 277 > 1-2 > 18-25

Social isolation is common in the elderly exerting negative effects on neuroimmunoendocrine communication. Nevertheless physiological responses to a stressful situation may vary according to diverse factors. This work studies the differences in the immune response of aged male rats socially isolated depending on the anxiety levels produced. Social isolation impaired certain immunological parameters,...

article

EARLY PERIPHERAL OXIDATIVE STRESS STATUS IN MALE AND FEMALE TRIPLE-TRANSGENIC MICE FOR ALZHEIMER'S DISEASE

Angel Hernanz, Carmen Vida, Rashed Manassra, Lydia Gimenez-Llort, more

Alzheimer's & Dementia: The Journal of the Alzheimer's Association > 2014 > 10 > 4 Supplement > P492-P493

article

LONGITUDINAL STUDY OF PERITONEAL IMMUNE CELLS AND AVERAGE LIFE EXPECTANCY OF TRIPLE-TRANSGENIC MICE FOR ALZHEIMER'S DISEASE

Ianire Maté, Mónica De la Fuente, Julia Cruces, Lydia Gimenez-Llort

Alzheimer's & Dementia: The Journal of the Alzheimer's Association > 2014 > 10 > 4 Supplement > P493-P494

article

Peripheral immune system and neuroimmune communication impairment in a mouse model of Alzheimer's disease

Lydia Giménez‐Llort, Ianire Maté, Rashed Manassra, Carmen Vida, more

Annals of the New York Academy of Sciences > 1262 > 1 > 74 - 84

Neurodegenerative diseases such as Alzheimer's disease (AD) can be understood in the context of the aging of neuroimmune communication. Although the contribution to AD of the immune cells present in the brain is accepted, the role of the peripheral immune system is less well known. The present review examines the behavior and the function and redox state of peripheral immune cells in a triple‐transgenic...

article

Comparison of the skeletal effects induced by daily administration of PTHrP (1–36) and PTHrP (107–139) to ovariectomized mice

Luis Fernández de Castro, Daniel Lozano, Sergio Portal‐Núñez, Marta Maycas, more

Journal of Cellular Physiology > 227 > 4 > 1752 - 1760

We here compared the changes induced by subcutaneous injection of PTHrP (1–36) or PTHrP (107–139) (80 µg/kg/day, 5 days/week for 4 or 8 weeks) in bone histology and bone remodeling factors, and in bone marrow cells (BMCs) ex vivo, in ovariectomized (OVX) mice. We also examined the osteogenic effects of these peptides in mouse mesenchymal C3H10T1/2 cells under oxidative stress condition in vitro, which...

article

Sulfur-containing antioxidants increase in vitro several functions of lymphocytes from mice

Mónica De la Fuente, Angel Hernanz, Salvador Viniegra, Jaime Miquel

International Immunopharmacology > 2011 > 11 > 6 > 661-669

The in vitro effects of several sulfur-containing antioxidants, such as glutathione (GSH), N-acetylcysteine (NAC), thioproline (TP) and taurine (TAU), at different concentrations, on key functions of lymphocytes from axillary nodes, spleen, thymus and peritoneum from young-adult BALB/c mice have been investigated. The functions studied have been proliferation, both spontaneous and in response to the...

article

Early onset of the impairment of neuroimmunoendocrine system in triple-transgenic 3xTg-AD mice

Lydia Gimenez-Llort, Carmen Vida, Núria M. de Castro, Isabel Baeza, more

Alzheimer's & Dementia > 2010 > 6 > 4(S) > S218

article

The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women

Lorena Arranz, Cesáreo Fernández, Antonio Rodríguez, José Manuel Ribera, more

Free Radical Biology and Medicine > 2008 > 45 > 9 > 1252-1262

Aging is a chronic oxidation process in which the immune system is involved. Because leukocyte function is a good health marker and longevity predictor, the effects of daily oral administration of N-acetylcysteine (NAC, 600 mg) on several lymphocyte (adherence, chemotaxis, proliferation, natural killer activity) and neutrophil (adherence, chemotaxis, phagocytosis, superoxide) functions, as well as...

article

Early maternal deprivation and neonatal single administration with a cannabinoid agonist induce long-term sex-dependent psychoimmunoendocrine effects in adolescent rats

Ricardo Llorente, Lorena Arranz, Eva-María Marco, Enrique Moreno, more

Psychoneuroendocrinology > 2007 > 32 > 6 > 636-650

Maternal deprivation [24h on postnatal day 9] might represent an animal model of schizophrenia and behavioural and neurochemical alterations observed in adulthood may be mediated by hippocampal impairments induced by abnormally increased glucocorticoids due to neonatal stress. We aimed to provide new data for psychoimmunoendocrine characterization of this animal model by evaluating its effects in...

article

Impairment of several immune functions in anxious women

Lorena Arranz, Noelia Guayerbas, Mónica De la Fuente

Journal of Psychosomatic Research > 2007 > 62 > 1 > 1-8

Controversial results concerning immune function changes taking place in anxious subjects have been obtained. The aim of the present work was to study immune function in a group of anxious women.Thirty-three anxious and 33 nonanxious age-matched women were included. Anxiety levels were determined by the Beck Anxiety Inventory. Peripheral blood samples were collected, and several leukocyte functions,...

article

Improvement of leukocyte functions in prematurely aging mice after five weeks of diet supplementation with polyphenol-rich cereals

Pedro Álvarez, Carmen Alvarado, Marta Puerto, Armelle Schlumberger, more

Nutrition > 2006 > 22 > 9 > 913-921

We investigated the beneficial effects of diet supplementation with two types of cereals naturally rich in polyphenolic compounds on several functions of peritoneal leukocytes from prematurely aging mice (PAM). Two-hundred sixty healthy mice, 8 wk of age, were recruited and their behavioral responses were tested in a simple T-maze to identify PAM. Then the mice were fed a diet supplemented with...

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INFONA - science communication portal

Search results for: Mónica De la Fuente

Aging is accompanied by T‐cell stiffening and reduced interstitial migration through dysfunctional nuclear organization

Improvement of Redox State and Functions of Immune Cells as Well as of Behavioral Response in Aged Mice After Two-Week Supplementation of Fermented Milk with Probiotics

High perceived stress in women is linked to oxidation, inflammation and immunosenescence

Social environment improves immune function and redox state in several organs from prematurely aging female mice and increases their lifespan

Protective effect of xanthohumol against age-related brain damage

Administration of a leptin antagonist during the neonatal leptin surge induces alterations in the redox and inflammatory state in peripubertal /adolescent rats

Parathyroid Hormone‐Related Protein Protects Osteoblastic Cells From Oxidative Stress by Activation of MKP1 Phosphatase

Hsp70 basal levels, a tissue marker of the rate of aging and longevity in mice

The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence

A higher anxiety state in old rats after social isolation is associated to an impairment of the immune response

EARLY PERIPHERAL OXIDATIVE STRESS STATUS IN MALE AND FEMALE TRIPLE-TRANSGENIC MICE FOR ALZHEIMER'S DISEASE

LONGITUDINAL STUDY OF PERITONEAL IMMUNE CELLS AND AVERAGE LIFE EXPECTANCY OF TRIPLE-TRANSGENIC MICE FOR ALZHEIMER'S DISEASE

Peripheral immune system and neuroimmune communication impairment in a mouse model of Alzheimer's disease

Comparison of the skeletal effects induced by daily administration of PTHrP (1–36) and PTHrP (107–139) to ovariectomized mice

Sulfur-containing antioxidants increase in vitro several functions of lymphocytes from mice

Early onset of the impairment of neuroimmunoendocrine system in triple-transgenic 3xTg-AD mice

The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women

Early maternal deprivation and neonatal single administration with a cannabinoid agonist induce long-term sex-dependent psychoimmunoendocrine effects in adolescent rats

Impairment of several immune functions in anxious women

Improvement of leukocyte functions in prematurely aging mice after five weeks of diet supplementation with polyphenol-rich cereals

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