Search results for: Lorena Arranz

Items from 1 to 13 out of 13 results

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Nestin-expressing progenitor cells: function, identity and therapeutic implications

Aurora Bernal, Lorena Arranz

Cellular and Molecular Life Sciences > 2018 > 75 > 12 > 2177-2195

The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cells. However, current extensive evidence obtained in in vivo models and humans shows presence of Nestin⁺ cells with progenitor and/or regulatory functions in a number of additional tissues, remarkably bone marrow. This review presents the current knowledge on the role...

article

Interleukin-1β as emerging therapeutic target in hematological malignancies and potentially in their complications

Lorena Arranz, Maria del Mar Arriero, Alicia Villatoro

Blood Reviews > 2017 > 31 > 5 > 306-317

Interleukin-1β (IL-1β) is a pleiotropic cytokine that exerts multiple roles in both physiological and pathological conditions. It is produced by different cell subsets, and drives a wide range of inflammatory responses in numerous target cells. Enhanced IL-1β signaling is a common event in patients of hematological malignancies. Recent body of evidence obtained in preclinical models shows the pathogenic...

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Estrogen Signaling Selectively Induces Apoptosis of Hematopoietic Progenitors and Myeloid Neoplasms without Harming Steady-State Hematopoiesis

Abel Sánchez-Aguilera, Lorena Arranz, Daniel Martín-Pérez, Andrés García-García, more

Cell Stem Cell > 2014 > 15 > 6 > 791-804

Estrogens are potent regulators of mature hematopoietic cells; however, their effects on primitive and malignant hematopoietic cells remain unclear. Using genetic and pharmacological approaches, we observed differential expression and function of estrogen receptors (ERs) in hematopoietic stem cell (HSC) and progenitor subsets. ERα activation with the selective ER modulator (SERM) tamoxifen induced...

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Circadian parasympathetic regulation of hematopoietic stem cell traffic

Andrés García, Lorena Arranz, Abel Sánchez-Aguilera, Matti Airaksinen, more

Experimental Hematology > 2013 > 41 > 8 Supplement > S14

article

Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion

Joan Isern, Beatriz Martín-Antonio, Roshanak Ghazanfari, Ana M. Martín, more

Cell Reports > 2013 > 3 > 5 > 1714-1724

Strategies for expanding hematopoietic stem cells (HSCs) include coculture with cells that recapitulate their natural microenvironment, such as bone marrow stromal stem/progenitor cells (BMSCs). Plastic-adherent BMSCs may be insufficient to preserve primitive HSCs. Here, we describe a method of isolating and culturing human BMSCs as nonadherent mesenchymal spheres. Human mesenspheres were derived...

article

Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage

Lorena Arranz, Alba Naudí, Mónica Fuente, Reinald Pamplona

AGE > 2013 > 35 > 3 > 621-635

Membrane unsaturation plays an important role in the aging process and the determination of inter-species animal longevity. Furthermore, the accumulation of oxidation-derived molecular damage to cellular components particularly in the nervous and immune systems over time leads to homeostasis loss, which highly influences age-related morbidity and mortality. In this context, it is of great interest...

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Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female mice similar to that in aged males

Isabel Baeza, Nuria M. Castro, Lorena Arranz, Jesús Fdez-Tresguerres, more

Biogerontology > 2011 > 12 > 3 > 227-238

Immunosenescence involves age-associated restructuring changes of innate and adaptative immune functions. We have suggested that these changes of the immune system participate in the rate of ageing through modulating oxi-inflamm-ageing. Thus, age-related changes in the immune system can be biological age markers and predictors of longevity. Gender differences in oxidation status and immune functions...

article

Preserved ex vivo inflammatory status and cytokine responses in naturally long-lived mice

Lorena Arranz, Janet M. Lord, Mónica Fuente

AGE > 2010 > 32 > 4 > 451-466

Preserved immune cell function has been reported in mice that achieve extreme longevity. Since cytokines are major modulators of immune responses, we aimed to determine the levels of 21 cytokines secreted ex vivo by peritoneal leukocytes cultured under basal- and mitogen- (conconavalin A (ConA) and LPS) stimulated conditions in middle-aged (44 ± 4 weeks), old (69 ± 4 weeks), very old (92 ± 4 weeks),...

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Differential expression of Toll-like receptor 2 and 4 on peritoneal leukocyte populations from long-lived and non-selected old female mice

Lorena Arranz, Nuria M. Castro, Isabel Baeza, Mónica Fuente

Biogerontology > 2010 > 11 > 4 > 475-482

The aim of the present study was to determine Toll-like receptor (TLR)-2 and TLR-4 membrane expression on the major peritoneal leukocyte populations throughout the aging process, including subjects that had achieved exceptional longevity. ICR (CD1) female mice of different ages: adult (44 ± 4 weeks), old (69 ± 4), very old (92 ± 4) and extreme long-lived (125 ± 4), were used. Peritoneal leukocytes...

article

The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women

Lorena Arranz, Cesáreo Fernández, Antonio Rodríguez, José Manuel Ribera, more

Free Radical Biology and Medicine > 2008 > 45 > 9 > 1252-1262

Aging is a chronic oxidation process in which the immune system is involved. Because leukocyte function is a good health marker and longevity predictor, the effects of daily oral administration of N-acetylcysteine (NAC, 600 mg) on several lymphocyte (adherence, chemotaxis, proliferation, natural killer activity) and neutrophil (adherence, chemotaxis, phagocytosis, superoxide) functions, as well as...

article

Early maternal deprivation and neonatal single administration with a cannabinoid agonist induce long-term sex-dependent psychoimmunoendocrine effects in adolescent rats

Ricardo Llorente, Lorena Arranz, Eva-María Marco, Enrique Moreno, more

Psychoneuroendocrinology > 2007 > 32 > 6 > 636-650

Maternal deprivation [24h on postnatal day 9] might represent an animal model of schizophrenia and behavioural and neurochemical alterations observed in adulthood may be mediated by hippocampal impairments induced by abnormally increased glucocorticoids due to neonatal stress. We aimed to provide new data for psychoimmunoendocrine characterization of this animal model by evaluating its effects in...

article

Impairment of several immune functions in anxious women

Lorena Arranz, Noelia Guayerbas, Mónica De la Fuente

Journal of Psychosomatic Research > 2007 > 62 > 1 > 1-8

Controversial results concerning immune function changes taking place in anxious subjects have been obtained. The aim of the present work was to study immune function in a group of anxious women.Thirty-three anxious and 33 nonanxious age-matched women were included. Anxiety levels were determined by the Beck Anxiety Inventory. Peripheral blood samples were collected, and several leukocyte functions,...

article

Behavioral, endocrine and immunological characteristics of a murine model of premature aging

Laura Pérez-Álvarez, Isabel Baeza, Lorena Arranz, Eva M. Marco, more

Developmental and Comparative Immunology > 2005 > 29 > 11 > 965-976

We have previously shown that differences in life span among members of Swiss mouse populations appear to be related to their exploration of a T-maze, with a slow exploration (‘slow mice’) being linked to alteration of spontaneous behavior and monoaminergic systems, impaired immune function and shorter life span. In general these traits resemble some of the characteristics of chronologically old animals...

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