Search results for: Joshua Cohen

Items from 1 to 20 out of 47 results

article

Reduced osseointegration in disuse and denervation rat models results from impaired cellular responses to multiscale microstructured titanium surfaces

Jingyao Deng, David Joshua Cohen, Enrique B. Matias, Lucas O. Olson, more

Journal of Orthopaedic Research® > 42 > 9 > 1984 - 1997

Immobilization‐induced skeletal unloading results in muscle atrophy and rapid bone loss, thereby increasing the risk of falling and the need for implant therapy in patients with extended bed rest or neuromuscular injuries. Skeletal unloading causes bone loss by altering bone growth and resorption, suggesting that implant performance might be affected. To test this, we focused on early events in implant...

article

Internal surface modification of additively manufactured macroporous TiAl6V4 biomimetic implants via a calciothermic reaction‐based process and osteogenic in vivo responses

Michael B. Berger, D. Joshua Cohen, Jingyao Deng, Pavan Srivas, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 112 > 1 > n/a - n/a

Three‐dimensional macroporous titanium–aluminum–vanadium (TiAl6V4) implants produced by additive manufacturing (AM) can be grit blasted (GB) to yield microtextured exterior surfaces, with additional micro/nano‐scale surface features provided by subsequent acid etching (AE). However, the line‐of‐sight nature of GB causes the topography of exterior GB + AE‐modified surfaces to differ from internal GB‐inaccessible...

article

Democratic responsibility in the digital public sphere

Joshua Cohen, Archon Fung

Constellations > 30 > 1 > 92 - 97

article

Bone marrow stromal cells are sensitive to discrete surface alterations in build and post‐build modifications of bioinspired Ti6Al4V 3D‐printed in vitro testing constructs

Michael B. Berger, D. Joshua Cohen, Kyle Snyder, John Sions, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 111 > 4 > 829 - 845

Current standards in bone‐facing implant fabrication by metal 3D (M3D) printing require post‐manufacturing modifications to create distinct surface properties and create implant microenvironments that promote osseointegration. However, the biological consequences of build parameters and surface modifications are not well understood. This study evaluated the relative contributions of build parameters...

article

miR‐122 and the WNT/β‐catenin pathway inhibit effects of both interleukin‐1β and tumor necrosis factor‐α in articular chondrocytes in vitro

Kayla M. Scott, D. Joshua Cohen, Barbara D. Boyan, Zvi Schwartz

Journal of Cellular Biochemistry > 123 > 6 > 1053 - 1063

Interleukin‐1β (IL‐1β), tumor necrosis factor‐α (TNF‐α), and WNT/β‐catenin signaling cause dysregulation of rat primary articular chondrocytes (rArCs), resulting in cartilage extracellular matrix destruction and osteoarthritis (OA) progression. microRNA (miR) miR‐122 represses these effects whereas miR‐451 exacerbates IL‐1β‐stimulated matrix metalloproteinase‐13 (MMP‐13) and prostaglandin E2 (PGE2)...

article

Growth factors produced by bone marrow stromal cells on nanoroughened titanium–aluminum–vanadium surfaces program distal MSCs into osteoblasts via BMP2 signaling

Michael B. Berger, Kyla B. Bosh, Thomas W. Jacobs, D. Joshua Cohen, more

Journal of Orthopaedic Research® > 39 > 9 > 1908 - 1920

Statement of Clinical Significance: There remains the need to develop materials and surfaces that can increase the rate of implant osseointegration. Though osteoanabolic agents, like bone morphogenetic protein (BMP), can provide signaling for osteogenesis, the appropriate design of implants can also produce an innate cellular response that may reduce or eliminate the need to use additional agents...

article

Long‐term survival of participants in the CENTAUR trial of sodium phenylbutyrate‐taurursodiol in amyotrophic lateral sclerosis

Sabrina Paganoni, Suzanne Hendrix, Samuel P. Dickson, Newman Knowlton, more

Muscle & Nerve > 63 > 1 > 31 - 39

An orally administered, fixed‐dose coformulation of sodium phenylbutyrate‐taurursodiol (PB‐TURSO) significantly slowed functional decline in a randomized, placebo‐controlled, phase 2 trial in ALS (CENTAUR). Herein we report results of a long‐term survival analysis of participants in CENTAUR. In CENTAUR, adults with ALS were randomized 2:1 to PB‐TURSO or placebo. Participants completing the 6‐month...

article

Production of osteogenic and angiogenic factors by microencapsulated adipose stem cells varies with culture conditions

Shirae K. Leslie, David Joshua Cohen, Barbara D. Boyan, Zvi Schwartz

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 108 > 5 > 1857 - 1867

Growth factors produced by stem cells aid in the bone repair process. We investigated the ability of encapsulated rat adipose‐derived stem cells (rASCs) treated with osteogenic media (OM) to produce growth factors, and determined the optimal combination of OM components that will lead to the production of both osteogenic and angiogenic factors. Our results demonstrate that microencapsulated stem cells...

article

Acellular mineralized allogenic block bone graft does not remodel during the 10 weeks following concurrent implant placement in a rabbit femoral model

D. Joshua Cohen, Kayla M. Scott, Aniket N. Kulkarni, Jennifer S. Wayne, more

Clinical Oral Implants Research > 31 > 1 > 37 - 48

Objectives Due to bone loss, endosseous implants often require addition of a bone graft to support adequate primary fixation, bone regeneration, and osseointegration. The aim of this study was to compare effectiveness of autogenic and allogenic bone grafts when used during simultaneous insertion of the implant. Materials and Methods 4‐mm‐diameter rabbit diaphyseal bone autografts or allografts...

article

The potential role of circulating tumor DNA (ctDNA) in the further investigation of colorectal cancer patients with nonspecific findings on standard investigations

Rachel Wong, Jeanne Tie, Margaret Lee, Joshua Cohen, more

International Journal of Cancer > 145 > 2 > 540 - 547

Early detection of metastatic colorectal cancer, at initial diagnosis or during routine surveillance, can improve survival outcomes. Current routine investigations, including CEA and CT, have limited sensitivity and specificity. Recent studies of colorectal cancer cohorts under post surgery surveillance indicate circulating tumor DNA (ctDNA) evidence of recurrence can occur many months before clinical...

article

Cost-effectiveness of colorectal cancer screening in Ukraine

Nelya Melnitchouk, Djøra I. Soeteman, Jennifer S. Davids, Adam Fields, more

Cost Effectiveness and Resource Allocation > 2018 > 16 > 1 > 1-9

Background Colorectal cancer is one of the most common cancers worldwide and is associated with high mortality when detected at a later stage. There is a paucity of studies from low and middle income countries to support the cost-effectiveness of colorectal cancer screening. We aim to analyze the cost-effectiveness of colorectal cancer screening compared to no screening in Ukraine, a lower-middle...

article

An RCT to Facilitate Implementation of School Practices Known to Increase Physical Activity

Rachel L. Sutherland, Nicole K. Nathan, David R. Lubans, Kristen Cohen, more

American Journal of Preventive Medicine > 2017 > 53 > 6 > 818-828

Although comprehensive school-based physical activity interventions are efficacious when tested under research conditions, they often require adaptation in order for implementation at scale. This paper reports the effectiveness of an adapted efficacious school-based intervention in improving children’s moderate to vigorous physical activity. The impact of strategies to support program implementation...

chapter

Study of calcium-dynamics in ultrasound-stimulated secretory events in pancreatic beta cells

Ivan Suarez Castellanos, Andrew Chen, Aleks Klimas, Emilia Entcheva, more

2017 IEEE International Ultrasonics Symposium (IUS) > 1

2017 IEEE International Ultrasonics Symposium (IUS)

Type 2 diabetes mellitus is a complex metabolic disease that has reached epidemic proportions. Current pharmacological treatments of this disease include many side effects which can result in complications. We have previously shown that ultrasound is capable of stimulating insulin release from pancreatic beta cells in a safe and effective manner. The aim of this work is to study the role of calcium...

chapter

Leveraging GPUs for handling large SAR data volumes for the NISAR mission

Joshua Cohen, Piyush Agram, Sean Buckley, Paul Rosen, more

2017 IEEE International Geoscience and Remote Sensing Symposium (IGARSS) > 4606 - 4609

IGARSS 2017 - 2017 IEEE International Geoscience and Remote Sensing Symposium

The NASA-ISRO Synthetic Aperture Radar (NISAR) mission [4] will redefine the future of earth science in terms of both the quality as well as the quantity of data that will be downlinked daily. The InSAR Scientific Computing Environment (ISCE) [1], a powerful, modular, and extensible framework, is expected to be used as the processing engine for generating tens of terabytes of SAR data products from...

article

Ultrasound Stimulation of Insulin Release from Pancreatic Beta Cells as a Potential Novel Treatment for Type 2 Diabetes

Ivan Suarez Castellanos, Aleksandar Jeremic, Joshua Cohen, Vesna Zderic

Ultrasound in Medicine & Biology > 2017 > 43 > 6 > 1210-1222

Type 2 diabetes mellitus is a complex metabolic disease that has reached epidemic proportions in the United States and around the world. This disease is characterized by loss of insulin secretion and, eventually, destruction of insulin-producing pancreatic beta cells. Controlling type 2 diabetes is often difficult as pharmacological management routinely requires complex therapy with multiple medications,...

chapter

Leveraging the usage of GPUs in SAR processing for the NISAR mission

Joshua Cohen, Piyush Agram

2017 IEEE Radar Conference (RadarConf) > 492 - 496

2017 IEEE Radar Conference (RadarConf17)

The NASA ISRO Synthetic Aperture Radar (NISAR) mission will redefine the future of earth science in terms of both the quality as well as the quantity of data that will be downlinked daily. The current software architecture used to process this data is the InSAR Scientific Computing Environment (ISCE), a powerful and modular platform that applies a combination of novel and legacy processing modules...

article

COST COMPARISON ACROSS HEART FAILURE PATIENTS WITH REDUCED AND PRESERVED EJECTION FRACTIONS: ANALYSES OF INPATIENT DECOMPENSATED HEART FAILURE ADMISSIONS

Natalia Olchanski, Amanda Vest, Pallavi Rane, Joshua Cohen, more

Journal of the American College of Cardiology > 2016 > 67 > 13(S) > 1469

article

Self-management of chronic illness: the role of ‘habit’ versus reflective factors in exercise and medication adherence

L. Alison Phillips, Joshua Cohen, Edith Burns, Jessica Abrams, more

Journal of Behavioral Medicine > 2016 > 39 > 6 > 1076-1091

Non-adherence to health behaviors required for chronic illness self-management is pervasive. Advancing health-behavior theory to include behavioral initiation and maintenance factors, including reflective (e.g., belief- and feedback-based) and automatic (e.g., habit-based) mechanisms of adherence to different treatment-related behaviors could improve non-adherence prediction and intervention efforts...

article

A framework for assessing the impact of pharmaceutical reimbursement policies on incentives to innovate

Elizabeth Docteur, Joshua Cohen, Brian K Bruen, Ruth Lopert, more

Journal of Pharmaceutical Policy and Practice > 2015 > 8 > 1 > 1-2

article

Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug

Tram T. Dang, Anh V. Thai, Joshua Cohen, Jeremy E. Slosberg, more

Biomaterials > 2013 > 34 > 23 > 5792-5801

Immuno-isolation of islets has the potential to enable the replacement of pancreatic function in diabetic patients. However, host response to the encapsulated islets frequently leads to fibrotic overgrowth with subsequent impairment of the transplanted grafts. Here, we identified and incorporated anti-inflammatory agents into islet-containing microcapsules to address this challenge. In vivo subcutaneous...

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INFONA - science communication portal

Search results for: Joshua Cohen

Reduced osseointegration in disuse and denervation rat models results from impaired cellular responses to multiscale microstructured titanium surfaces

Internal surface modification of additively manufactured macroporous TiAl6V4 biomimetic implants via a calciothermic reaction‐based process and osteogenic in vivo responses

Democratic responsibility in the digital public sphere

Bone marrow stromal cells are sensitive to discrete surface alterations in build and post‐build modifications of bioinspired Ti6Al4V 3D‐printed in vitro testing constructs

miR‐122 and the WNT/β‐catenin pathway inhibit effects of both interleukin‐1β and tumor necrosis factor‐α in articular chondrocytes in vitro

Growth factors produced by bone marrow stromal cells on nanoroughened titanium–aluminum–vanadium surfaces program distal MSCs into osteoblasts via BMP2 signaling

Long‐term survival of participants in the CENTAUR trial of sodium phenylbutyrate‐taurursodiol in amyotrophic lateral sclerosis

Production of osteogenic and angiogenic factors by microencapsulated adipose stem cells varies with culture conditions

Acellular mineralized allogenic block bone graft does not remodel during the 10 weeks following concurrent implant placement in a rabbit femoral model

The potential role of circulating tumor DNA (ctDNA) in the further investigation of colorectal cancer patients with nonspecific findings on standard investigations

Cost-effectiveness of colorectal cancer screening in Ukraine

An RCT to Facilitate Implementation of School Practices Known to Increase Physical Activity

Study of calcium-dynamics in ultrasound-stimulated secretory events in pancreatic beta cells

Leveraging GPUs for handling large SAR data volumes for the NISAR mission

Ultrasound Stimulation of Insulin Release from Pancreatic Beta Cells as a Potential Novel Treatment for Type 2 Diabetes

Leveraging the usage of GPUs in SAR processing for the NISAR mission

COST COMPARISON ACROSS HEART FAILURE PATIENTS WITH REDUCED AND PRESERVED EJECTION FRACTIONS: ANALYSES OF INPATIENT DECOMPENSATED HEART FAILURE ADMISSIONS

Self-management of chronic illness: the role of ‘habit’ versus reflective factors in exercise and medication adherence

A framework for assessing the impact of pharmaceutical reimbursement policies on incentives to innovate

Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug

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