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INTRODUCTION: Social support during exposure-based psychotherapy has been suggested to have an important influence on the course of exposure treatment, however some clinical trials show that individual therapy may be more effective than group therapy. The mechanisms of social influence on fear extinction remain unknown. METHOD(S): To study neuronal correlates of social buffering in fear extinction,...
The α‐Ca2+/calmodulin‐dependent protein kinase II (αCaMKII), a key regulator of the glutamatergic synapse, has been implicated in many psychiatric disorders characterized by social impairments. Here we tested whether autophosphorylation of αCaMKII at threonine 286, which prolongs the activity of the enzyme, affects social behaviors in mice. We observed that autophosphorylation‐deficient (αCaMKII‐T286A)...
INTRODUCTION: Lately, we can observe a steady increase in the number of autism spectrum disorder (ASD) diagnoses every year. ASD is often connected with empathy impairments, a phenomenon thought to be limited only to humans, yet the simplest form of empathy, emotional contagion, can be examined also in rodents. AIM(S): In our previous study we have shown that C57BL/6 mice are capable of transferring...
Autism spectrum disorders (ASD) are a group of behaviorally defined neurodevelopmental disorders characterized with three core symptom clusters: social behavior impairments, deficient communication and in creased repetitive behaviors. The etiology of the disease remains poorly understood as many factors seem to contribute to ASD phenotype. Several mutations in genes encoding synaptic proteins have...
The experiment was designed to examine whether the relationship between anxiety level and social behavior depends on sex in animal model of individual differences (Roman RHA/RLA rats). Hyperemotional RLA and hypoemotional RHA males and females were subjected to a set of nonsocial (OF, EPM) and social tests. Females were tested during selected phase of ovary cycle – estrus or diestrus. Social settings...
Ketamine, phencyclidine and MK801 are uncompetitive NMDA receptor (NMDAR) antagonists which are used widely to model certain features of schizophrenia in rats. Systemic administration of NMDAR antagonists, in addition to provoking an increase in c-Fos expression, leads to important neurochemical and electrophysiological changes within the medial prefrontal cortex (mPFC). Since the mPFC is considered...
Matrix metalloproteinases are a major group of enzymes regulating cell-matrix composition, which are essential for many biological processes. Matrix Metalloproteinase-9 (MMP-9) has recently emerged as an important molecule in control of extracellular proteolysis in the synaptic plasticity. Using conventional transgenesis, we have created rats with overexpression of MMP-9 limited to the neurons of...
In humans subanesthetic doses of noncompetitive NMDA receptor (NMDAR) antagonists can produce symptoms similar to those observed in schizophrenia. In rodents, systemic application of NMDAR antagonists produce hyperactivity, stereotypies and abnormal social interactions used to model certain features of schizophrenia. It was also shown that NMDAR antagonists induce the high frequency oscillations (HFO,...
The psychogenetically selected Roman High (RHA/Verh) and Roman Low (RLA/Verh) Avoidance rats constitute a widely accepted model of diverse emotional reactivity. They show divergent stressrelated behavioral and neuronal responses when confronted with a novel and/or stressogenic environment (Meyza et al. 2009). Here, we have explored the possibility that the difference might be also refl ected in the...
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