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Sea anemone actinoporins constitute an optimum model to investigate mechanisms of membrane pore formation. All actinoporins of known structure show a general fold of a β‐sandwich motif flanked by two α‐helices. The crucial structure for pore formation seems to be the helix located at the N‐terminal end. The role of several other protein regions in membrane attachment is also well established. However,...
Actinoporins are a family of sea anemone proteins that bind to membranes and produce functional pores which result in cell lysis. Actinoporin variants with decreased lytic activity usually show a reduced affinity for membranes. However, for some of these mutant versions there is no direct correlation between the loss of binding affinity and the decrease in their overall lytic activity, suggesting...
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