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We studied the effects of alendronate (amino-hydroxybutylidene bisphosphonate) on biochemical indices of bone turnover and on lumbar spinal bone mineral density in 15 postmenopausal women with vertebral osteoporosis. Alendronate 7.5 mg daily was administered intravenously as a slow infusion for four consecutive days. Treatment was associated with a significant decrease in serum calcium (p < 0...
We evaluated the biochemical and histomorphometric effects of a modified ADFR regimen in postmenopausal osteoporosis. Twenty women received oral phosphate (1500mg/day) for 6 months and 5 single infusions of clodronate (300mg each month) (n=10) or 5 single infusions of clodronate alone (300mg each month) (n=10).Clodronate alone significantly decreased serum alkaline phosphatase activity (-11%, p<0...
The measurement of bone mineral has predictive value in identifying elderly individuals at increased risk of fracture, but other factors including poor muscle strength, are also associated with fracture, particularly at the hip. Since muscle exerts a tropic effect on the skeleton a positive relationship might be expected between muscle strength and bone density.We have examined the relationship between...
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