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Bisphosphonates are widely used in disorders associated with increased resorption of bone, particularly in Paget's disease of bone and the hypercalcaemia of malignancy. Their undoubted efficacy and relatively low toxicity makes them attractive candidates for the management of osteoporosis. The three bisphosphonates widely tested are etidronate, pamidronate and clodronate. Whereas pamidronate can only...
We evaluated the biochemical and histomorphometric effects of a modified ADFR regimen in postmenopausal osteoporosis. Twenty women received oral phosphate (1500mg/day) for 6 months and 5 single infusions of clodronate (300mg each month) (n=10) or 5 single infusions of clodronate alone (300mg each month) (n=10).Clodronate alone significantly decreased serum alkaline phosphatase activity (-11%, p<0...
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