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Infantile spasms (IS) is an age-related epileptic disorder characterized by specific spasms, hypsarrhythmia and mental retardation. Most of IS patients can not get spasm free under the available treatment and prognosis is poor. It is crucial to develop new effective drugs the treatment of IS. Histamine H3 receptor antagonist seems to be effective in some epilepsy models. Betahistine is one of H3 antagonists...
In order to explore the effects of initial polytherapy by combining ACTH followed by prednisone, topiramate, IVIG and vitamin B6 in newly diagnosed West syndrome. 51 children with West syndrome were included in our study. Forty-six patients became spasm-free through polytheray, two children effective and three ineffective. Statistical difference in time to spasm free was found between cryptogenetic...
We present an implicit approach for pair-wise non-rigid registration of moving and deforming objects. Shapes of interest are implicitly embedded in the 3D implicit vector space. In this implicit embedding space, registration is performed using a global-to-local framework. Firstly, a non-linear optimization functional defined on the vector distance function is used to find the global alignment between...
The metallurgical observation and measurement analysis of the chip morphology and cutting force in high-speed turning of AISI-1045 hardened steel were performed. The influences of workpiece material hardness, cutting condition, serrated chip morphology and adiabatic shear instability on cutting force were analysed. The investigations indicate that two types of serrated chips with deformed adiabatic...
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