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Our previous work indicated exposure of Human liver cell 7702 (HL7702) cells to Microcystin‐leucine‐arginine (MC‐LR) for 24 hours can disrupt insulin (INS) signaling by the hyperphosphorylation of specific proteins. For further exploring the time‐dependent effect posed by MC‐LR on this pathway, in the current study, HL7702 cells together with mice were exposed to the MC‐LR with different concentrations...
Microcystin‐LR (MC‐LR) is a widely produced monocyclic heptapeptides in eutrophication waterbodies. MC‐LR can induce various toxic effects in different cells. Our previous studies have found that MC‐LR exposure can disrupt insulin signaling pathway in human liver cells (HL 7702). Skeletal muscle is one of the major organs for glucose disposal and responsive to insulin. However, the effects of MC‐LR...
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