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• Ageing is associated with increased risk of sudden cardiac death due to malignant arrhythmias.
• Shortened refractoriness of Ca2+ release due to increased activity of Ca2+ release channels (RyRs) is recognized as an important contributor to cardiac‐triggered arrhythmias. However, molecular mechanisms of RyR dysfunction and its contribution to arrhythmias in ageing remain to be examined.
• Using...
Postpubertal women with inherited long QT syndrome type 2 (LQT2) are at increased risk for polymorphic ventricular tachycardia (pVT) and sudden cardiac death (SCD), particularly during the postpartum period. To investigate whether sex hormones directly modulate the arrhythmogenic risk in LQTS. Prepubertal ovariectomized transgenic LQT2 rabbits were treated with estradiol (EST), progesterone...
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