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Polymeric micelles with a hydrophobic core represent versatile nanostructures for encapsulation and delivery of water‐insoluble drugs. Here, water‐insoluble beclometasone dipropionate (BDP) which is a potent anti‐inflammatory therapeutic agent but limited to topical applications so far, is encapsulated. Therefore, this work used an amphiphilic block copolymer self‐assembling into flexible polymeric...
Wormlike Polymer Micelles
In article number 2306482, Andreas Stallmach, Johannes C. Brendel, and co‐workers found that wormlike polymer micelles in contrast to spherical structures translocate selectively into inflamed intestinal mucosa without affecting healthy tissue. Entering the lamina propria, the micelles further passively target only immune cells of the inflamed biopsy, which is key for effective...
Inflammatory bowel disease (IBD) has become a globally prevalent chronic disease with no causal therapeutic options. Targeted drug delivery systems with selectivity for inflamed areas in the gastrointestinal tract promise to reduce severe drug‐related side effects. By creating three distinct nanostructures (vesicles, spherical, and wormlike micelles) from the same amphiphilic block copolymer poly(butyl...
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