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Corneal neovascularization (CoNV) is a major cause of visual impairment worldwide. Currently, available treatment options have limited efficacy and are associated with adverse effects due to biological barriers and clearance mechanisms. To address this challenge, a novel topical delivery system is developed—Gel 2_1&Eylea—an aflibercept‐loaded eye‐drop hydrogel mediated with cell‐penetrating peptide...