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Significant non‐genetic stochastic factors affect aging, causing lifespan differences among individuals, even those sharing the same genetic and environmental background. In Caenorhabditis elegans, differences in heat‐shock response (HSR) are predictive of lifespan. However, factors contributing to the heterogeneity of HSR are still not fully elucidated. Here, the authors characterized HSR dynamics...
In article number 2102145, Collin Y. Ewald, Rudiyanto Gunawan, and co‐workers highlight a microfluidic device used for sorting adult C. elegans populations—in a high‐throughput manner—based on individual GFP expression. The heterogeneous dynamic heat‐shock response, its relation to proteostasis, and how it can predict lifespan are thoroughly studied. Image credit: Mrs. Yujia Ma.
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