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In article number 2000655, Po‐Liang Lai, Hsing‐Wen Sung, and co‐workers present a hollow microsphere system that may function as an incubator for the generation and delivery of NO in a scavenger‐free environment. Upon leaving the incubator, the NO molecules may passively diffuse through their protected‐surfactant layer gradually to the tumor site, performing long‐lasting radiosensitization.
Nitric oxide (NO) is a potent tumor‐cell radiosensitizer but it can be readily scavenged by hemoglobin (Hb) in vivo. A biomimetic incubator that can generate and deliver NO in a scavenger (Hb)‐free environment to enhance its radiosensitizing effect to maximize its efficacy in radiotherapy is proposed. This NO incubator comprises a poly(lactic‐co‐glycolic acid) (PLGA) hollow microsphere (HM) that contains...
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