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Objective
Status epilepticus is a life‐threatening neurological emergency. However, delay in median time to administration of second‐line antiseizure medication exists. The aim of this quality improvement initiative was to decrease the average delay before fosphenytoin is administered for pediatric patients with generalized convulsive status epilepticus from 30 min (baseline data collected in 2013)...
Background
Recent genomic profiling has identified a subtype of prostate cancer (PCa) characterized by two key genetic alterations: missense mutation of speckle‐type POZ protein (SPOP) and homozygous deletion of chromodomain helicase DNA‐binding protein 1 (CHD1). Mutually exclusive with E26 transformation‐specific (ETS) rearrangements, this subtype displays high genomic instability. Previous studies...
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