Search results for: Ofer Ben‐Izhak

Items from 1 to 20 out of 34 results

article

Three-step management of a newborn with a giant, highly vascularized, cervical teratoma: a case report

Ori Hochwald, Ziv Gil, Arie Gordin, Zeev Winer, more

Journal of Medical Case Reports > 2019 > 13 > 1 > 1-5

Background A giant congenital cervical teratoma is often highly vascularized; thus, in addition to a life-threatening airway occlusion at birth it comprises a high risk for significant and lethal blood loss during resection. In the case presented, an endovascular embolization of the carotid artery that supplied a giant congenital cervical teratoma was done as part of a three-stage treatment soon after...

article

Cancer‐associated fibroblasts are an infrequent finding in the microenvironment of proliferative verrucous leukoplakia‐associated squamous cell carcinoma

Sharon J. Akrish, Adi Rachmiel, Edmond Sabo, Marilena Vered, more

Journal of Oral Pathology & Medicine > 46 > 5 > 353 - 358

Background Cancer‐associated fibroblasts (CAFs) are generally associated with negative prognostic factors. This study compares the clinicopathologic impact of CAFs in oral squamous cell carcinoma in patients with a history of proliferative verrucous leukoplakia (p‐scca) and patients with conventional squamous cell carcinoma of the buccal mucosa, gingiva, and palate (c‐scca). Methods A retrospective...

article

Computerized cytometry and wavelet analysis of follicular lesions for detecting malignancy: A pilot study in thyroid cytology

Hayim Gilshtein, Michal Mekel, Leonid Malkin, Ofer Ben-Izhak, more

Surgery > 2017 > 161 > 1 > 212-219

The cytologic diagnosis of indeterminate lesions of the thyroid involves much uncertainty, and the final diagnosis often requires operative resection. Computerized cytomorphometry and wavelets analysis were examined to evaluate their ability to better discriminate between benign and malignant lesions based on cytology slides.Cytologic reports from patients who underwent thyroid operation in a single,...

article

Angiosarcoma arising in association with vascular Dacron grafts and orthopedic joint prostheses: clinicopathologic, immunohistochemical, and molecular study

Abbas Agaimy, Ofer Ben-Izhak, Thomas Lorey, Marcus Scharpf, more

Annals of Diagnostic Pathology > 2016 > 21 > Complete > 21-28

Angiosarcoma may rarely arise near an inert foreign body material including vascular grafts and metal joint prostheses. Sixteen such cases have been reported since 1972 but mostly in the radiologic or surgical literature without detailed histologic or molecular analyses. We herein describe the clinicopathologic and molecular features of 2 new cases and reanalyzed 3 previously reported cases of angiosarcoma...

article

Oral squamous cell carcinoma associated with proliferative verrucous leukoplakia compared with conventional squamous cell carcinoma—a clinical, histologic and immunohistochemical study

Sharon Akrish, Ofer Ben-Izhak, Edmond Sabo, Adi Rachmiel

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology > 2015 > 119 > 3 > 318-325

Proliferative verrucous leukoplakia (PVL), a potentially malignant disorder, often undergoes malignant transformation to oral squamous cell carcinoma. The aim of our study was to document and compare the histologic, immunohistochemical, and clinical features and the survival rates of carcinoma arising in patients with PVL (p-scca) with conventional squamous cell carcinoma (c-scca) in order to determine...

article

Adenoma and carcinoma components in colonic tumors show discordance for KRAS mutation

Dov Hershkovitz, Einav Simon, Tova Bick, Elad Prinz, more

Human Pathology > 2014 > 45 > 9 > 1866-1871

Activating mutations in KRAS are common events in the pathogenesis of colorectal carcinoma and predict response to treatment with anti-EGFR antibodies. Molecular pathology testing for KRAS mutations has become the standard of practice for patients with metastatic colorectal carcinoma. Despite the known histologic and molecular differences between adenomas and carcinomas, the concordance of KRAS mutation...

article

Su1303 Early Histological Findings May Predict the Clinical Phenotype in Crohn's Colitis

Amir Klein, Amir Karban, Yoav Mazor, Ofer Ben-Izhak, more

Gastroenterology > 2014 > 146 > 5 Supplement 1 > S-431

article

KRAS mutation positive mucinous adenocarcinoma originating in mature ovarian teratoma: Case report and review of literature

Dov Hershkovitz, Euvgeni Vlodavsky, Einav Simon, Ofer Ben‐Izhak

Pathology International > 63 > 12 > 611 - 614

Mature ovarian teratomas rarely undergo transformation into malignancy. Carcinomas, mostly squamous cell carcinoma, are the most common malignancy arising in mature cystic teratoma. In the present report we describe a 13‐year‐old girl who developed a large mass in her ovary. Fine needle biopsy identified intestinal type mucinous adenocarcinoma, which was also identified in the full surgical specimen...

article

Normal colon tissue and colon carcinoma show no difference in heparanase promoter methylation

Yehudit Peerless, Einav Simon, Edmond Sabo, Ofer Ben-Izhak, more

Experimental and Molecular Pathology > 2013 > 94 > 2 > 309-313

Heparanase, the sole heparan sulfate degrading enzyme, has a role in cellular invasion. Accordingly, a large number of studies have demonstrated an association between heparanase expression and tumor stage and patients' prognosis. In colon carcinoma, heparanase shows increased expression in tumor compared to normal tissue and its expression correlates with the presence of metastasis. One of the regulatory...

article

165 Early Histological Findings Quantified by Histomorphometry Allow Prediction of Clinical Phenotype in Crohn's Colitis

Amir Klein, Abraham R. Eliakim, Amir Karaban, Yoav Mazor, more

Gastroenterology > 2012 > 142 > 5 Supplement 1 > S-41

article

P27/SKP-2 Histochemical Profile is Relevant to Malignant Salivary Gland Tumors (MST) Histogenesis and Tumor Grade

Sharon Akrish, Ofer Ben-Izhak, Micha Peled

Head and Neck Pathology > 2012 > 6 > 2 > 157-165

Malignant salivary gland tumors (MST) represent over more than 24 distinct morphological subtypes. Most high grade tumors arise from the excretory duct portion of the salivary gland apparatus; the remainder from the intercalated duct portion. Altered p27/skp-2 expression has been associated with tumor aggressiveness and histologic differentiation. In our study, we analyzed p27/skp-2 expression proteins...

article

Prognostic value of heparanase expression and cellular localization in oral cancer

Yoav Leiser, Imad Abu‐El‐Naaj, Edmond Sabo, Sharon Akrish, more

Head & Neck > 33 > 6 > 871 - 877

BackgroundMetastases formation depends on the ability of tumor cells to invade basement membranes in a process involving enzymes capable of degrading extracellular matrix components. MethodsWe examined the expression of heparanase in oral carcinomas and correlated its staining extent, intensity, and cellular localization with patients' outcome. ResultsQuantitative real‐time polymerase chain reaction...

article

Molecular morphometric analysis shows relative intra-tumoural homogeneity for KRAS mutations in colorectal cancer

Liora Farber, Edna Efrati, Hela Elkin, Yehudit Peerless, more

Virchows Archiv > 2011 > 459 > 5 > 487-493

KRAS mutation status has a significant role determining anti-epidermal growth factor receptor (anti-EGFR) treatment response in colon carcinoma patients. Malignant transformation is a dynamic process and therefore, it is conceivable that, at a certain point, the tumor cells’ mass might be heterogeneous for particular mutations. Therefore, the fraction of tumor cells carrying a particular mutation...

article

Oral cancer, cigarette smoke and mitochondrial 18kDa translocator protein (TSPO) — In vitro, in vivo, salivary analysis

Rafael Nagler, Ofer Ben-Izhak, Dana Savulescu, Ella Krayzler, more

BBA - Molecular Basis of Disease > 2010 > 1802 > 5 > 454-461

Oral cancer features high rates of mortality and morbidity, and is in dire need for new approaches. In the present study we analyzed 18kDa translocator protein (TSPO) expression in oral (tongue) cancer tumors by immunohistochemistry. We also assayed TSPO binding in human tongue cancer cell lines and in the cellular fraction of saliva from tongue cancer patients, heavy cigarette smokers, and non-smoking...

article

The prognostic role of phospho-Src family kinase analysis in tongue cancer

Ofer Ben-Izhak, Victoria Cohen-Kaplan, Rafael M. Nagler

Journal of Cancer Research and Clinical Oncology > 2010 > 136 > 1 > 27-34

Background The up regulation of Phospho-Src family kinase oncogene has been correlated with reduced post-operative survival in various cancers but never in tongue cancer. Methods We analyzed phospho-Src family kinase in 39 tongue (mobile) cancer patients by immunohistochemistry, compared these results with similar analysis for TUNEL and c-erbB-2 and with both clinical tumor characteristics and patient...

article

Malignant salivary gland tumors and cyclo-oxygenase-2: A histopathological and immunohistochemical analysis with implications on histogenesis

Sharon Akrish, Micha Peled, Ofer Ben-Izhak, Rafi M. Nagler

Oral Oncology > 2009 > 45 > 12 > 1044-1050

The classification system for malignant salivary gland tumors (MST) is largely dependent on its histogenesis. The histogenesis is uncertain but the “bicellular theory of origin” has been accepted by most and states that malignant transformation of reserve cells from either the intercalated or excretory duct are responsible for the development of MST. Cyclooxygenase-2 (cox-2), a potential molecular...

article

p27 and salivary cancer

Ofer Ben-Izhak, Sharon Akrish, Shlomit Gan, Rafael M. Nagler

Cancer Immunology, Immunotherapy > 2009 > 58 > 3 > 469-473

This study examined p27 expression in a cohort of salivary malignancies (n = 74) for a prolonged period (20 years). Reduction of p27 expression was found to be a most powerful predictor for poor survival and more so when the tumor concurrently expressed high levels of p53, TUNEL and heparanase markers, dramatically dropping the patient survival probability to 0! While no patient whose tumor-staining...

article

Over-expression of Skp2 is associated with resistance to preoperative doxorubicin-based chemotherapy in primary breast cancer

Shirly Davidovich, Ofer Ben-Izhak, Ma'anit Shapira, Boris Futerman, more

Breast Cancer Research > 2008 > 10 > 4 > 1-10

Introduction Preoperative chemotherapy is often used in patients with locally advanced breast cancer. However, commonly used clinical and pathological parameters are poor predictors of response to this type of therapy. Recent studies have suggested that altered regulation of the cell cycle in cancer may be involved in resistance to chemotherapy. Over-expression of the ubiquitin ligase Skp2 results...

article

W1981 Lysyl Oxidase Like Protein 2 (Loxl2) and Loxl3 Expression Is Up-Regulated in Colorectal Carcinoma

Matti Waterman, Shelly Zafriar, Rami Eliakim, Ofer Ben-Izhak, more

Gastroenterology > 2008 > 134 > 4 Supplement 1 > A-747

article

Expression of the Ubiquitin Ligase Subunit Cyclin Kinase Subunit 1 and its Relationship to S-Phase Kinase Protein 2 and p27Kip1 in Prostate Cancer

Ma’anit Shapira, Ofer Ben-Izhak, Merav Slotky, Oleg Goldin, more

The Journal of Urology > 2006 > 176 > 5 > 2285-2289

Loss of the cell cycle inhibitory protein p27 ^Kip1 in cancer is associated with tumor aggressiveness and poor prognosis in the prostate. The decrease in p27 ^Kip1 results from increased proteasome dependent degradation, which is mediated by its specific ubiquitin ligase subunits S-phase kinase protein 2 and cyclin dependent kinase subunit 1. S-phase kinase protein 2 was found to be...

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Search results for: Ofer Ben‐Izhak

Three-step management of a newborn with a giant, highly vascularized, cervical teratoma: a case report

Cancer‐associated fibroblasts are an infrequent finding in the microenvironment of proliferative verrucous leukoplakia‐associated squamous cell carcinoma

Computerized cytometry and wavelet analysis of follicular lesions for detecting malignancy: A pilot study in thyroid cytology

Angiosarcoma arising in association with vascular Dacron grafts and orthopedic joint prostheses: clinicopathologic, immunohistochemical, and molecular study

Oral squamous cell carcinoma associated with proliferative verrucous leukoplakia compared with conventional squamous cell carcinoma—a clinical, histologic and immunohistochemical study

Adenoma and carcinoma components in colonic tumors show discordance for KRAS mutation

Su1303 Early Histological Findings May Predict the Clinical Phenotype in Crohn's Colitis

KRAS mutation positive mucinous adenocarcinoma originating in mature ovarian teratoma: Case report and review of literature

Normal colon tissue and colon carcinoma show no difference in heparanase promoter methylation

165 Early Histological Findings Quantified by Histomorphometry Allow Prediction of Clinical Phenotype in Crohn's Colitis

P27/SKP-2 Histochemical Profile is Relevant to Malignant Salivary Gland Tumors (MST) Histogenesis and Tumor Grade

Prognostic value of heparanase expression and cellular localization in oral cancer

Molecular morphometric analysis shows relative intra-tumoural homogeneity for KRAS mutations in colorectal cancer

Oral cancer, cigarette smoke and mitochondrial 18kDa translocator protein (TSPO) — In vitro, in vivo, salivary analysis

The prognostic role of phospho-Src family kinase analysis in tongue cancer

Malignant salivary gland tumors and cyclo-oxygenase-2: A histopathological and immunohistochemical analysis with implications on histogenesis

p27 and salivary cancer

Over-expression of Skp2 is associated with resistance to preoperative doxorubicin-based chemotherapy in primary breast cancer

W1981 Lysyl Oxidase Like Protein 2 (Loxl2) and Loxl3 Expression Is Up-Regulated in Colorectal Carcinoma

Expression of the Ubiquitin Ligase Subunit Cyclin Kinase Subunit 1 and its Relationship to S-Phase Kinase Protein 2 and p27Kip1 in Prostate Cancer

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