Search results for: Kayo Yoshikawa

Items from 1 to 16 out of 16 results

article

Heart‐rate evaluation using fetal ultrasonic Doppler during neonatal resuscitation

Kazunori Kayama, Shigeharu Hosono, Kayo Yoshikawa, Ryota Kato, more

Pediatrics International > 62 > 8 > 926 - 931

Background The objective of the present study was to verify the speed and accuracy of fetal ultrasonic Doppler (fetal Doppler) in measuring heart rate of newborns at rest, including preterm, low‐birthweight infants, and its efficacy during neonatal resuscitation, including cases of neonatal asphyxia. Methods A three‐lead electrocardiogram and fetal Doppler were used to measure resting heart rates...

article

Intestinal Failure-Associated Liver Disease and Eicosapentaenoic Acid/Arachidonic Acid Ratio

Wataru Miura, Nobuhiko Nagano, Ryota Kato, Aya Okahashi, more

The Indian Journal of Pediatrics > 2019 > 86 > 6 > 548-550

Intestinal failure-associated liver disease (IFALD) is a fatal complication of short bowel syndrome managed with parenteral nutrition. A clinical cohort study reported the usefulness of parenteral administration of fish-derived omega-3 fatty acids in improving IFALD; however, no biomarker has been developed as yet. The authors report the case of a preterm infant with IFALD complicated by extensive...

article

Hemolytic disease of the newborn due to anti‐E and anti‐c antibody following maternal transfusion

Midori Yoda, Shigeharu Hosono, Nobuhiko Nagano, Kayo Yoshikawa, more

Pediatrics International > 59 > 10 > 1093 - 1094

article

Congenital adrenal hyperplasia and violation of newborn screening procedures

Hitomi Odajima, Shigeharu Hosono, Kazunori Kayama, Kayo Yoshikawa, more

Pediatrics International > 59 > 10 > 1107 - 1108

article

Target value of oxygen saturation during the first 10 min after birth

Yosuke Taguchi, Shigeharu Hosono, Kazunori Kayama, Ryota Kato, more

Pediatrics International > 59 > 10 > 1064 - 1068

Background During neonatal resuscitation, careful oxygenation is needed. Pulse oximetry is recommended to evaluate the need for oxygenation, but it is not clear whether peripheral perfusion is adequate for the evaluation of arterial oxygen saturation (SpO₂). Additionally, there has been no study on the changes in SpO₂ immediately after birth in Japan, despite the indispensable need for definitive...

article

Alveolar capillary dysplasia with misalignment of the pulmonary veins due to novel insertion mutation of FOXF1

Nobuhiko Nagano, Kayo Yoshikawa, Shigeharu Hosono, Shori Takahashi, more

Pediatrics International > 58 > 12 > 1371 - 1372

article

Residual blood volume in the umbilical cord of extremely premature infants

Shigeharu Hosono, Kotaro Hine, Nobuhiko Nagano, Yosuke Taguchi, more

Pediatrics International > 57 > 1 > 68 - 71

Background The aim of this study was to investigate residual blood volume in the umbilical cord of extremely premature infants. Methods Twenty extremely premature infants were held at or below the placenta while the umbilical cord was clamped and cut at approximately 2–3 cm from the umbilicus within 30 s after birth. The umbilical cord was then clamped near the placenta to obtain a length of approximately...

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Gray matter volumetric MRI differences late-preterm and term infants

Shun Munakata, Tomoo Okada, Aya Okahashi, Kayo Yoshikawa, more

Brain and Development > 2013 > 35 > 1 > 10-16

Gray matter develops rapidly during the third trimester of pregnancy, which is a critical period for lipid deposition. We measured brain volume in term and late-preterm infants to determine if it is related to disabilities in late-preterm infants. In addition, we measured serum lipid concentrations to investigate the relationship between brain volume and lipid nutrition. Magnetic resonance imaging...

article

Treatment responses for disseminated intravascular coagulation in 25 children treated with recombinant thrombomodulin: A single institution experience

Hiroshi Yagasaki, Maiko Kato, Katsuyoshi Shimozawa, Maiko Hirai, more

Thrombosis Research > 2012 > 130 > 6 > e289-e293

Recombinant thrombomodulin (rTM), which degrades factors Va and VIIIa by activating protein C, has been developed as a new drug for treating disseminated intravascular coagulation (DIC).Since July 2009, we have treated 25 children with DIC using rTM (380U/kg/day, or 130U/kg/day for newborns) as a first-line therapy. Median duration of rTM administration was 5 consecutive days (range, 2–13days). We...

article

Early postnatal changes of lipoprotein subclass profile in late preterm infants

Nobuhiko Nagano, Tomoo Okada, Ryuta Yonezawa, Kayo Yoshikawa, more

Clinica Chimica Acta > 2012 > 413 > 1-2 > 109-112

Late preterm infants (LPIs; 34–37 gestational weeks at birth) have higher risk for several morbidities than do term infants (TIs). It has been suggested that a cholesterol and fatty acid supply may improve their outcomes. We investigated the lipoprotein subclass profile in LPIs to evaluate their early postnatal lipid metabolism.Eighty-one infants (25 LPIs, 56 TIs) were included. Cholesterol and triglyceride...

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Incorporation of Biaryl Units into the 5′ and 3′ Ends of Sense and Antisense Strands of siRNA Duplexes Improves Strand Selectivity and Nuclease Resistance

Kayo Yoshikawa, Aya Ogata, Chiho Matsuda, Michinori Kohara, more

Bioconjugate Chemistry > 2011 > 22 > 1 > 42 - 49

article

Synthesis of nuclease-resistant siRNAs possessing universal overhangs

Yoshihito Ueno, Yuuji Watanabe, Aya Shibata, Kayo Yoshikawa, more

Bioorganic & Medicinal Chemistry > 2009 > 17 > 5 > 1974-1981

RNA interference (RNAi) induced by small interfering RNA (siRNA) has emerged as a powerful technique for the silencing of gene expression at the post-transcriptional level. It has been shown that in the RNAi machinery, the 3′-overhang region of a guide strand (an antisense strand) of siRNA is recognized by the PAZ domain in the Argonaute protein, and the 2-nucleotide (nt) 3′-overhang is accommodated...

article

Effect of incorporation of alkyl linkers into siRNAs on RNA interference

Yoshihito Ueno, Kayo Yoshikawa, Yoshiaki Kitamura, Yukio Kitade

Bioorganic & Medicinal Chemistry Letters > 2009 > 19 > 3 > 875-877

Unintended (off-target) transcript silencing is a critical problem associated with RNA interference (RNAi)-based therapeutic applications. This paper shows that the incorporation of appropriate alkyl linkers at the center of the sense strands can suppress the off-target effects induced by the sense strands without reducing the RNAi-inducing activity of the antisense strands.

article

Synthesis and properties of siRNAs containing 5′-amino-2′,5′-dideoxy-2′α-fluororibonucleosides

Yoshihito Ueno, Miki Hirai, Kayo Yoshikawa, Yoshiaki Kitamura, more

Tetrahedron > 2008 > 64 > 49 > 11328- 11334

Short interfering RNAs (siRNAs) containing P3′→N5′ phosphoramidate linkages were successfully synthesized by introducing 2′-deoxy-2′-fluororibonucleoside and 5′-amino-2′,5′-dideoxy-2′α-fluororibonucleoside in succession. It was found that the introduction of 5′-amino-2′,5′-dideoxy-2′α-fluororibonucleosides into siRNAs improved the nuclease-resistant properties of the siRNAs without loss of their silencing...

article

Synthesis of nuclease-resistant siRNAs possessing benzene-phosphate backbones in their 3′-overhang regions

Yoshihito Ueno, Takumi Inoue, Mahito Yoshida, Kayo Yoshikawa, more

Bioorganic & Medicinal Chemistry Letters > 2008 > 18 > 19 > 5194-5196

We describe the synthesis and silencing activities of siRNA possessing N ¹ -[3,5-bis(hydroxymethyl)phenyl]thymine (b ^t ) in their 3′-overhang regions. We found that an siRNA possessing b ^t in the 3′-overhang region was more effective than an siRNA with natural nucleosides and the siRNA possessing 1,3-bis(hydroxymethyl)benzene (b) without a nucleobase at the 3′-overhang region...

article

Synthesis and silencing properties of siRNAs possessing lipophilic groups at their 3′-termini

Yoshihito Ueno, Koshi Kawada, Tomoharu Naito, Aya Shibata, more

Bioorganic & Medicinal Chemistry > 2008 > 16 > 16 > 7698-7704

Short-interfering RNAs (siRNAs) conjugated with lipophilic groups at their 3′-termini were synthesized. The properties of the synthesized siRNAs were examined in detail, and it was found that at low concentrations, their silencing abilities were dependent on the positions of the modifications and the types of organic molecules attached. Although the modification of siRNAs with palmitic acid or oleic...

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