Search results for: Mamoru Tochigi

Items from 1 to 20 out of 52 results

article

Mutations of the glycine cleavage system genes possibly affect the negative symptoms of schizophrenia through metabolomic profile changes

Akane Yoshikawa, Fumichika Nishimura, Aya Inai, Yosuke Eriguchi, more

Psychiatry and Clinical Neurosciences > 72 > 3 > 168 - 179

Aim Hypofunction of N‐methyl‐D‐aspartate receptors (NMDAR) may contribute to the pathophysiology of schizophrenia (SCZ). Recently, the glycine cleavage system (GCS) was shown to affect NMDAR function in the brain. GCS functional defects cause nonketotic hyperglycinemia, the atypical phenotype of which presents psychiatric symptoms similar to SCZ. Here, we examined the involvement of GCS in SCZ. ...

article

Epigenome-wide association study of DNA methylation in panic disorder

Mihoko Shimada-Sugimoto, Takeshi Otowa, Taku Miyagawa, Tadashi Umekage, more

Clinical Epigenetics > 2017 > 9 > 1 > 1-11

Background Panic disorder (PD) is considered to be a multifactorial disorder emerging from interactions among multiple genetic and environmental factors. To date, although genetic studies reported several susceptibility genes with PD, few of them were replicated and the pathogenesis of PD remains to be clarified. Epigenetics is considered to play an important role in etiology of complex traits and...

article

Annual longitudinal survey at up to five time points reveals reciprocal effects of bedtime delay and depression/anxiety in adolescents

Mamoru Tochigi, Satoshi Usami, Misato Matamura, Yuko Kitagawa, more

Sleep Medicine > 2016 > 17 > C > 81-86

To investigate the longitudinal relationship between sleep habits and mental health in adolescents.Multipoint observation data of up to five years were employed from a prospective cohort study of sleep habits and mental health status conducted from 2009 to 2013 in a unified junior and senior high school (grades 7–12) in Tokyo, Japan. A total of 1078 students answered a self-report questionnaire, including...

article

Effect of metabotropic glutamate receptor-3 variants on prefrontal brain activity in schizophrenia: An imaging genetics study using multi-channel near-infrared spectroscopy

Akihide Kinoshita, Ryu Takizawa, Shinsuke Koike, Yoshihiro Satomura, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 2015 > 62 > Complete > 14-21

The glutamatergic system is essential for learning and memory through its crucial role in neural development and synaptic plasticity. Genes associated with the glutamatergic system, including metabotropic glutamate receptor (mGluR or GRM) genes, have been implicated in the pathophysiology of schizophrenia. Few studies, however, have investigated a relationship between polymorphism of glutamate-related...

article

Graves' hyperthyroidism‐induced psychosis in a patient with periventricular nodular heterotopia

Gaku Oshikubo, Mamoru Tochigi, Akihisa Akahane, Naoki Hayashi, more

Psychiatry and Clinical Neurosciences > 69 > 8 > 505 - 506

article

DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons

Gabriel Oh, Sun-Chong Wang, Mrinal Pal, Zheng Fei Chen, more

Biological Psychiatry > 2015 > 77 > 3 > 246-255

Major depressive disorder (MDD) exhibits numerous clinical and molecular features that are consistent with putative epigenetic misregulation. Despite growing interest in epigenetic studies of psychiatric diseases, the methodologies guiding such studies have not been well defined. We performed DNA modification analysis in white blood cells from monozygotic twins discordant for MDD, in brain prefrontal...

article

Anger tendency may be associated with duration of illness in panic disorder

Nagisa Sugaya, Eiji Yoshida, Shin Yasuda, Mamoru Tochigi, more

BioPsychoSocial Medicine > 2015 > 9 > 1 > 1-7

Background Several studies have reported an increased tendency towards anger in patients with panic disorder (PD). If this propensity for anger arises from the pathological process of PD, it may be associated with the duration of the illness. The present study therefore examined the relationship between duration of PD and the personality tendency to experience anger in PD patients. Methods Participants...

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Gene×gene×gender interaction of BDNF and COMT genotypes associated with panic disorder

Yoshiaki Konishi, Hisashi Tanii, Takeshi Otowa, Tsukasa Sasaki, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 2014 > 51 > Complete > 119-125

Genetic and gender differences are among the factors that have a role in the etiology of panic disorder (PD). It is thought that PD is related to neurotransmitter pathways, such as brain-derived neurotrophic factor (BDNF) and catechol-O-methyltransferase (COMT), both of which are involved in the regulation of the monoamine mechanism. We examined the interactions of BDNF, COMT and gender differences...

article

Associations between sleep habits and mental health status and suicidality in a longitudinal survey of monozygotic twin adolescents

Misato Matamura, Mamoru Tochigi, Satoshi Usami, Hiromi Yonehara, more

Journal of Sleep Research > 23 > 3 > 292 - 296

Several epidemiological studies have indicated that there is a relationship between sleep habits, such as sleep duration, bedtime and bedtime regularity, and mental health status, including depression and anxiety in adolescents. However, it is still to be clarified whether the relationship is direct cause‐and‐effect or mediated by the influence of genetic and other traits, i.e. quasi‐correlation....

article

Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals

Yukika Nishimura, Ryu Takizawa, Shinsuke Koike, Akihide Kinoshita, more

NeuroImage > 2014 > 85 > Part 1 > 527-534

The early growth response 3 (EGR3) gene is an immediate early gene that is expressed throughout the brain and has been suggested as a potential susceptibility gene for schizophrenia (SZ). EGR3 impairment is associated with various neurodevelopmental dysfunctions, and some animal studies have reported a role for EGR3 function in the prefrontal cortex. Therefore, EGR3 genotype variation may be reflected...

article

Genetic influences on prefrontal activation during a verbal fluency task in adults: A twin study based on multichannel near-infrared spectroscopy

Eisuke Sakakibara, Ryu Takizawa, Yukika Nishimura, Shingo Kawasaki, more

NeuroImage > 2014 > 85 > Part 1 > 508-517

Near-infrared spectroscopy (NIRS) studies have reported that prefrontal hemodynamic dysfunction during executive function tasks may be a promising biomarker of psychiatric disorders, because its portability and noninvasiveness allow easy measurements in clinical settings. Here, we investigated the degree to which prefrontal NIRS signals are genetically determined. Using a 52-channel NIRS system, we...

article

DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients

Tempei Ikegame, Miki Bundo, Fumiko Sunaga, Tatsuro Asai, more

Neuroscience Research > 2013 > 77 > 4 > 208-214

Accumulating evidence suggests that epigenetic alterations in brain-derived neurotrophic factor (BDNF) promoters are associated with the pathophysiology of psychiatric disorders. Epigenetic changes in BDNF were reported not only in brain tissues but also in other tissues, including peripheral blood cells (PBC) and saliva. We examined DNA methylation levels of BDNF promoters I and IV using genomic...

article

Irritable bowel syndrome, its cognition, anxiety sensitivity, and anticipatory anxiety in panic disorder patients

Nagisa Sugaya, Eiji Yoshida, Shin Yasuda, Mamoru Tochigi, more

Psychiatry and Clinical Neurosciences > 67 > 6 > 397 - 404

AimThe present study examined the effect of irritable bowel syndrome (IBS), cognitive appraisal of IBS, and anxiety sensitivity on anticipatory anxiety (AA) and agoraphobia (AG) in patients with panic disorder (PD). MethodsWe examined 244 PD patients who completed a set of questionnaires that included the Rome II Modular Questionnaire to assess the presence of IBS, the Anxiety Sensitivity Index (ASI),...

article

Prevalence of bipolar disorder in panic disorder patients in the Japanese population

Nagisa Sugaya, Eiji Yoshida, Shin Yasuda, Mamoru Tochigi, more

Journal of Affective Disorders > 2013 > 147 > 1-3 > 411-415

We examined the rate of bipolar I (BPD-I) and bipolar II disorders (BPD-II) in panic disorder (PD) patients, and compared clinical and psychological variables between PD patients with and without bipolar disorders (BPD).Participants were 649 Japanese patients with PD (215 men and 434 women, 38.49±10.40 years) at outpatient clinics for anxiety disorders. Constructive interviews using the Mini-International...

article

Season of birth effect on psychotic-like experiences in Japanese adolescents

Mamoru Tochigi, Atsushi Nishida, Shinji Shimodera, Yuji Okazaki, more

European Child & Adolescent Psychiatry > 2013 > 22 > 2 > 89-93

A number of studies have investigated seasonality of birth in schizophrenia. Most of the studies have consistently observed an excess of winter births, often associated with decreased summer births. We postulated that psychotic-like experiences (PLEs), subclinical hallucinatory and delusional experiences, may also be affected by birth season. In the present study, we assessed the season of birth effect...

article

A two-stage case–control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population

Yuichiro Watanabe, Jun Egawa, Yoshimi Iijima, Ayako Nunokawa, more

Schizophrenia Research > 2012 > 137 > 1-3 > 264-266

article

Reply to: Neurogenetic Effects of OXTR rs2254298 in the Extended Limbic System of Healthy Caucasian Adults

Hidenori Yamasue, Motomu Suga, Noriaki Yahata, Hideyuki Inoue, more

Biological Psychiatry > 2011 > 70 > 9 > e41-e42

article

No association between CLOCK gene 3111C/T polymorphism and personality traits in healthy Japanese subjects

Takeshi Otowa, Mamoru Tochigi, Tadashi Umekage, Takashi Ebisawa, more

Psychiatry and Clinical Neurosciences > 65 > 6 > 604 - 604

article

Association between EGR3 gene polymorphism and prefrontal hemodynamic response during cognitive task in patients with schizophrenia

Yukika Nishimura, Ryu Takizawa, Shinsuke Koike, Mamoru Tochigi, more

Neuroscience Research > 2011 > 71 > Supplement > e395

article

Effect of GRM3 gene polymorphism on cerebral blood flow in category fluencytask: A NIRS study

Akihide Kinoshita, Ryu Takizawa, Yukika Nishimura, Kouhei Marumo, more

Neuroscience Research > 2011 > 71 > Supplement > e393

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Search results for: Mamoru Tochigi

Mutations of the glycine cleavage system genes possibly affect the negative symptoms of schizophrenia through metabolomic profile changes

Epigenome-wide association study of DNA methylation in panic disorder

Annual longitudinal survey at up to five time points reveals reciprocal effects of bedtime delay and depression/anxiety in adolescents

Effect of metabotropic glutamate receptor-3 variants on prefrontal brain activity in schizophrenia: An imaging genetics study using multi-channel near-infrared spectroscopy

Graves' hyperthyroidism‐induced psychosis in a patient with periventricular nodular heterotopia

DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons

Anger tendency may be associated with duration of illness in panic disorder

Gene×gene×gender interaction of BDNF and COMT genotypes associated with panic disorder

Associations between sleep habits and mental health status and suicidality in a longitudinal survey of monozygotic twin adolescents

Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals

Genetic influences on prefrontal activation during a verbal fluency task in adults: A twin study based on multichannel near-infrared spectroscopy

DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients

Irritable bowel syndrome, its cognition, anxiety sensitivity, and anticipatory anxiety in panic disorder patients

Prevalence of bipolar disorder in panic disorder patients in the Japanese population

Season of birth effect on psychotic-like experiences in Japanese adolescents

A two-stage case–control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population

Reply to: Neurogenetic Effects of OXTR rs2254298 in the Extended Limbic System of Healthy Caucasian Adults

No association between CLOCK gene 3111C/T polymorphism and personality traits in healthy Japanese subjects

Association between EGR3 gene polymorphism and prefrontal hemodynamic response during cognitive task in patients with schizophrenia

Effect of GRM3 gene polymorphism on cerebral blood flow in category fluencytask: A NIRS study

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