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Background Prevalent non‐motor symptoms of Parkinson’s disease (PD) include gastrointestinal motor impairments and advanced stage PD displays pathological aggregates of α‐synuclein in colonic enteric neurons. We previously showed that 12 months old mice overexpressing human wild type (WT) α‐synuclein under the Thy1 promoter (Thy1‐aSyn) displayed colonic motor dysfunction. We investigated functional...
This paper proposes a novel methodology for the optimal and simultaneous designs of both Hermitian transforms and masks for reducing the intraclass separations of feature vectors for anomaly detection of diabetic retinopathy images. Each class of training images associates with a Hermitian transform, a mask and a known represented feature vector. The optimal and simultaneous designs of both the Hermitian...
In ultrasound elastography, axial strains of the examined tissue are calculated by the differentiation of the measured axial displacements. However, the results become obscured as high-frequency noise is amplified by the gradient operator. In this paper, we propose an advanced denoising method for axial displacements with the aim of accurately estimating their axial strains. The proposed algorithm...
This work is concerned with a novel denoising scheme based on repeated filtering in consecutive fractional Fourier transform domains. In particular, we leverage the effectiveness of a recently presented filter circuit for biomechanical signals into the case of kinematic signals with multiple impacts. The presented method generates a time-varying cutoff threshold that can accommodate the frequency...
In ultrasound elastography, tissue axial strains are obtained through the differentiation of axial displacements. However, the application of the gradient operator amplifies the noise present in the displacement rendering unreadable axial strains. In this paper a novel denoising scheme based on repeated filtering in consecutive fractional Fourier transform domains is proposed for the accurate estimation...
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