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Purpose: To investigate how kainic acid–induced epileptiform activity is related to hemodynamic changes probed by blood oxygenation level–dependent functional magnetic resonance imaging (BOLD fMRI).
Methods: Epileptiform activity was induced with kainic acid (KA) (10 mg/kg, i.p.), and simultaneous fMRI at 7 Tesla, and deep electrode local field potential (LFP) recordings were performed from the...
The aim of this study was to explain the temporal variations between subjects in the blood oxygenation level‐dependent (BOLD) response. Somatosensory responses were elicited with the electrical forepaw stimulus at a frequency of 10 Hz in urethane‐anesthetized rats, and functional magnetic resonance imaging (fMRI) with BOLD contrast and local field potential (LFP) measurements were performed simultaneously...
Simultaneous electrophysiological and functional magnetic resonance imaging measurements of animal models of epilepsy are methodologically challenging, but essential to better understand abnormal brain activity and hemodynamics during seizures. In this study, functional magnetic resonance imaging of medetomidine‐sedated rats was performed using novel rapid acquisition by sequential excitation and...
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