Search results for: Mark A. Tarnopolsky

Items from 1 to 20 out of 74 results

article

Circulating exosome‐like vesicle and skeletal muscle microRNAs are altered with age and resistance training

Donald Xhuti, Mats I. Nilsson, Katherine Manta, Mark A. Tarnopolsky, more

The Journal of Physiology > 601 > 22 > 5051 - 5073

Abstract The age‐related loss of skeletal muscle mass and functionality, known as sarcopenia, is a critical risk factor for morbidity and all‐cause mortality. Resistance exercise training (RET) is the primary countermeasure to fight sarcopenia and ageing. Altered intercellular communication is a hallmark of ageing, which is not well elucidated. Circulating extracellular vesicles (EVs), including...

article

Human skeletal muscle mitochondrial responses to single‐leg intermittent or continuous cycle exercise training matched for absolute intensity and total work

Lauren E. Skelly, Martin J. MacInnis, William Bostad, Devin G. McCarthy, more

Scandinavian Journal of Medicine & Science in Sports > 33 > 6 > 872 - 881

There is renewed interest in the potential for interval (INT) training to increase skeletal muscle mitochondrial content including whether the response differs from continuous (CONT) training. Comparisons of INT and CONT exercise are impacted by the manner in which protocols are “matched”, particularly with respect to exercise intensity, as well as inter‐individual differences in training responses...

article

COVID‐19‐Associated Critical Illness Myopathy with Direct Viral Effects

Dubravka Dodig, Mark A. Tarnopolsky, Marta Margeta, Katerina Gordon, more

Annals of Neurology > 91 > 4 > 568 - 574

Coronavirus disease 2019 (COVID‐19) severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2 infection) can lead to intensive care unit (ICU) admission and critical illness myopathy (CIM). We examined 3 ICU patients with COVID‐19 who required mechanical ventilation for pneumonia and developed CIM. Pathological examination of the skeletal muscle biopsies revealed myopathic changes consistent with...

article

Immune‐mediated necrotizing myopathy after BNT162b2 vaccination in a patient with antibodies against receptor‐binding domain of SARS‐CoV‐2 and signal recognition particle

Dubravka Dodig, Marvin J. Fritzler, Ali Naraghi, Mark A. Tarnopolsky, more

Muscle & Nerve > 65 > 4 > E11 - E13

article

Obesity and muscle‐macrophage crosstalk in humans and mice: A systematic review

Srikesh Rudrapatna, Meha Bhatt, Kuan‐Wen Wang, Rachel Bierbrier, more

Obesity Reviews > 20 > 11 > 1572 - 1596

Obesity is associated with the production of inflammatory cytokines that are implicated in insulin resistance (IR), and if not addressed, can lead to type 2 diabetes (T2D). The role of the immune system in skeletal muscle (SM) inflammation and insulin sensitivity is not yet well characterized. As SM IR is an important determinant of glycaemia, it is critical that the muscle‐immune phenotype is mapped...

article

Myopathies Related to Glycogen Metabolism Disorders

Mark A. Tarnopolsky

Neurotherapeutics > 2018 > 15 > 4 > 915-927

Most of the glycogen metabolism disorders that affect skeletal muscle involve enzymes in glycogenolysis (myophosphorylase (PYGM), glycogen debranching enzyme (AGL), phosphorylase b kinase (PHKB)) and glycolysis (phosphofructokinase (PFK), phosphoglycerate mutase (PGAM2), aldolase A (ALDOA), β-enolase (ENO3)); however, 3 involve glycogen synthesis (glycogenin-1 (GYG1), glycogen synthase (GSE), and...

article

Blunted satellite cell response is associated with dysregulated IGF-1 expression after exercise with age

Daniel R. Moore, Bryon R. McKay, Mark A. Tarnopolsky, Gianni Parise

European Journal of Applied Physiology > 2018 > 118 > 10 > 2225-2231

Purpose Insulin-like growth factor-1 (IGF-1) regulates protein synthesis and cell cycle kinetics. Given that aging is associated with anabolic resistance, we sought to determine if the attenuated exercise-induced satellite cell (SC) expression in older muscle is associated with a blunted IGF-1 response. Methods SC expression (Pax7⁺ cells) and protein (Western blot) and mRNA (RT-PCR) expression of...

article

The prognosis for glycemic status among children and youth with obesity 2 years after entering a weight management program

Reem Al Khalifah, Lehana Thabane, Mark A Tarnopolsky, Katherine M Morrison

Pediatric Diabetes > 19 > 5 > 874 - 881

Background To address gaps in knowledge of the longitudinal trajectory of dysglycemia in children with obesity, this study aimed to: (1) describe the changes in glycemic status over 2 years; (2) establish a predictive model for development of prediabetes among children with euglycemia; and (3) evaluate the influence of change in body mass index (BMI) z‐score on glycemic status. Methods Children...

article

Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes

Cynthia M. F. Monaco, Meghan C. Hughes, Sofhia V. Ramos, Nina E. Varah, more

Diabetologia > 2018 > 61 > 6 > 1411-1423

Aims/hypothesis A comprehensive assessment of skeletal muscle ultrastructure and mitochondrial bioenergetics has not been undertaken in individuals with type 1 diabetes. This study aimed to systematically assess skeletal muscle mitochondrial phenotype in young adults with type 1 diabetes. Methods Physically active, young adults (men and women) with type 1 diabetes (HbA_1c 63.0 ± 16.0 mmol/mol [7...

article

Superior mitochondrial adaptations in human skeletal muscle after interval compared to continuous single‐leg cycling matched for total work

Martin J. MacInnis, Evelyn Zacharewicz, Brian J. Martin, Maria E. Haikalis, more

The Journal of Physiology > 595 > 9 > 2955 - 2968

Key points A classic unresolved issue in human integrative physiology involves the role of exercise intensity, duration and volume in regulating skeletal muscle adaptations to training. We employed counterweighted single‐leg cycling as a unique within‐subject model to investigate the role of exercise intensity in promoting training‐induced increases in skeletal muscle mitochondrial content. Six...

article

Perspectives on Exertional Rhabdomyolysis

Eric S. Rawson, Priscilla M. Clarkson, Mark A. Tarnopolsky

Sports Medicine > 2017 > 47 > 1 > 33-49

Exertional (exercise-induced) rhabdomyolysis is a potentially life threatening condition that has been the subject of research, intense discussion, and media attention. The causes of rhabdomyolysis are numerous and can include direct muscle injury, unaccustomed exercise, ischemia, extreme temperatures, electrolyte abnormalities, endocrinologic conditions, genetic disorders, autoimmune disorders, infections,...

article

Effect of sex on the acute skeletal muscle response to sprint interval exercise

Lauren E. Skelly, Jenna B. Gillen, Martin J. MacInnis, Brian J. Martin, more

Experimental Physiology > 102 > 3 > 354 - 365

New Findings What is the central question of this study? Are there sex‐based differences in the acute skeletal muscle response to sprint interval training (SIT)? What is the main finding and its importance? In response to a SIT protocol that involved three 20 s bouts of ‘all‐out’ cycling, the expression of multiple genes associated with mitochondrial biogenesis, metabolic control and structural...

article

Males With MECP2 C-terminal-Related Atypical Rett Syndromes and Their Carrier Mothers

Gabriel M. Ronen, Lauren I. Brady, Mark A. Tarnopolsky

Pediatric Neurology > 2017 > 67 > C > 98-101

This communication examines the expanding phenotypes of the MECP2 C-terminal atypical Rett syndromes in males and their affected carrier mothers.We describe three males with normal karyotypes who presented with congenital evolving complex neurodevelopmental encephalopathies with multifaceted symptomatology of hypotonia, epilepsy, ataxia, spasticity, movement disorders, behavioral issues, severe intellectual...

article

Two novel mitochondrial tRNA mutations, A7495G (tRNASer(UCN)) and C5577T (tRNATrp), are associated with seizures and cardiac dysfunction

Djurdja Djordjevic, Lauren Brady, Renkui Bai, Mark A. Tarnopolsky

Mitochondrion > 2016 > 31 > C > 40-44

We describe here two novel mitochondrial mutations associated with a complex mitochondrial encephalopathy. An A to G transition at position 7495 (MT-TS1 (MT-tRNSer(UCN))) was identified at 83% heteroplasmy in the muscle of a four year old female with ptosis, hypotonia, seizures, and dilated cardiomyopathy (Case 1). A homoplasmic C to T transition at position 5577 (MT-TW (MT-tRNATrp)) was found in...

article

Mutations in TBCK, Encoding TBC1-Domain-Containing Kinase, Lead to a Recognizable Syndrome of Intellectual Disability and Hypotonia

Elizabeth J. Bhoj, Dong Li, Margaret Harr, Shimon Edvardson, more

The American Journal of Human Genetics > 2016 > 98 > 4 > 782-788

Through an international multi-center collaboration, 13 individuals from nine unrelated families and affected by likely pathogenic biallelic variants in TBC1-domain-containing kinase (TBCK) were identified through whole-exome sequencing. All affected individuals were found to share a core phenotype of intellectual disability and hypotonia, and many had seizures and showed brain atrophy and white-matter...

article

Meteorin-like and irisin — Effective therapies to treat diet-induced obesity and glucose intolerance?

Ayesha Saleem, Adeel Safdar, Mahmood Akhtar, Mark A. Tarnopolsky

Mitochondrion > 2015 > 24 > Supplement > S41-S42

article

EXERsomes induce systemic mitochondrial rejuvenation and ameliorate diet-induced obesity: Thinking inside the box for a change!

Adeel Safdar, Ayesha Saleem, Mahmood Akhtar, Aisha Nazli, more

Mitochondrion > 2015 > 24 > Supplement > S28

article

Rotenone-elevated mitochondrial respiration with inflammatory myopathies indicates a secondary impairment to NADH: Ubiquinone oxidoreductase that attenuates succinate dehydrogenase activity

Lauren G. MacNeil, Murray A. Potter, Mark A. Tarnopolsky

Mitochondrion > 2015 > 24 > Supplement > S36

article

Dysfunctional mitochondria? Let's make more… exercise in a bottle

Mark A. Tarnopolsky, Adeel Safdar

Mitochondrion > 2015 > 24 > Supplement > S4

article

The genomic era is here — A new standard of care in epilepsy? Case examples

Julie M. Eggington, Mark A. Tarnopolsky, Derek A. Nielsen, Eric P. Nelson, more

Epilepsy & Behavior > 2015 > 46 > C > 59

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INFONA - science communication portal

Search results for: Mark A. Tarnopolsky

Circulating exosome‐like vesicle and skeletal muscle microRNAs are altered with age and resistance training

Human skeletal muscle mitochondrial responses to single‐leg intermittent or continuous cycle exercise training matched for absolute intensity and total work

COVID‐19‐Associated Critical Illness Myopathy with Direct Viral Effects

Immune‐mediated necrotizing myopathy after BNT162b2 vaccination in a patient with antibodies against receptor‐binding domain of SARS‐CoV‐2 and signal recognition particle

Obesity and muscle‐macrophage crosstalk in humans and mice: A systematic review

Myopathies Related to Glycogen Metabolism Disorders

Blunted satellite cell response is associated with dysregulated IGF-1 expression after exercise with age

The prognosis for glycemic status among children and youth with obesity 2 years after entering a weight management program

Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes

Superior mitochondrial adaptations in human skeletal muscle after interval compared to continuous single‐leg cycling matched for total work

Perspectives on Exertional Rhabdomyolysis

Effect of sex on the acute skeletal muscle response to sprint interval exercise

Males With MECP2 C-terminal-Related Atypical Rett Syndromes and Their Carrier Mothers

Two novel mitochondrial tRNA mutations, A7495G (tRNASer(UCN)) and C5577T (tRNATrp), are associated with seizures and cardiac dysfunction

Mutations in TBCK, Encoding TBC1-Domain-Containing Kinase, Lead to a Recognizable Syndrome of Intellectual Disability and Hypotonia

Meteorin-like and irisin — Effective therapies to treat diet-induced obesity and glucose intolerance?

EXERsomes induce systemic mitochondrial rejuvenation and ameliorate diet-induced obesity: Thinking inside the box for a change!

Rotenone-elevated mitochondrial respiration with inflammatory myopathies indicates a secondary impairment to NADH: Ubiquinone oxidoreductase that attenuates succinate dehydrogenase activity

Dysfunctional mitochondria? Let's make more… exercise in a bottle

The genomic era is here — A new standard of care in epilepsy? Case examples

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