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The priming of T cells in the liver is widely accepted. Nonetheless, it is controversial whether immune activation in autoimmune hepatitis (AIH) occurs in the liver or in the spleen. To address this issue, we splenectomized mice and induced experimental murine AIH (emAIH) with an adenovirus (Ad)‐expressing formiminotransferase cyclodeaminase (FTCD). Post‐splenectomy, the experimental mice developed...