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Energy balance is regulated by circulating leptin concentrations and hypothalamic leptin receptor (ObRb) signaling via STAT3 but is inhibited by SOCS3 and PTP1B. Leptin signaling enhances anorexigenic neuropeptides and receptor (POMC, MC3‐R, MC4‐R) activation while suppressing orexigenic neuropeptides (NPY, AgRP). We investigated in a sex‐specific manner the early (PN2) and late (PN21) postnatal hypothalamic...