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Prostaglandin E2 (PGE2) plays crucial roles in managing microglial activation through the prostanoid EP2 receptor, a PGE2 receptor subtype. In this study, we report that PGE2 enhances interferon‐γ (IFN‐γ)‐induced nitric oxide production in microglia. IFN‐γ increased the release of nitrite, a metabolite of nitric oxide, which was augmented by PGE2, although PGE2 by itself slightly affects nitrite...