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Brain dysfunction is a prerequisite for critical complications in children with hand, foot, and mouth disease (HFMD). Aquaporin 4 (AQP‐4) may be involved in the pathological process of cerebral oedema and injury in children with severe and critical HFMD. This study aimed to assess the association of AQP‐4 with the severity of enterovirus 71 (EV71)–associated HFMD. Children with EV71‐infected HFMD...