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It is well known that the number of mast cells increases in a variety of fibrotic skin diseases, such as keroid, wound healing or systemic scleroderma. However, the role of human mast cells in fibrosis has not been completely understood. In the present study, we asked if the co-culture of human fibroblasts with functionally active human mast cells and mast cell-derived mediators could affect fibroblast...
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