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Chorea-acanthocytosis (ChAc) is a hereditary neurodegenerative disease showing Huntington disease-like neuropsychiatric symptoms and peripheral blood red cell acanthocytosis. Recently, we have identified the gene, CHAC, encoding a newly discovered protein, chorein, in which a deletion mutation was found in three Japanese ChAc families. Although four patients possessed the same mutation homozygously,...
BackgroundConventional automated hematology analyzers have limitations in platelet measurements such as poor accuracy and precision in the low count range and interference by nonplatelet particles. In order to improve it, the newly developed XN‐Series automated hematology analyzers (Sysmex Corporation, Kobe, Japan) have been installed with a new dedicated channel for platelet analysis (PLT‐F), which...
mTOR controls cell growth, in part by regulating p70 S6 kinase α (p70α) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding protein that also binds 4EBP1 and p70α. The binding of raptor to mTOR is necessary for the mTOR-catalyzed phosphorylation of 4EBP1 in vitro, and it strongly enhances the mTOR kinase activity toward p70α. Rapamycin or amino acid withdrawal...
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