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Eukaryotic genomes are packaged into chromatin by histone proteins whose chemical modification can profoundly influence gene expression. The histone modifications often act in combinations, which exert different effects on gene expression. Although a number of experimental techniques and data analysis methods have been developed to study histone modifications, it is still very difficult to identify...
In-depth analysis of the recent five experimental nucleosome datasets reveals the broad disagreements between the final nucleosome positions detected by the previous studies. Using signal processing methods, we found two distinct nucleosome distribution domains which evidently emerge from promoter and coding regions. We calculated and confirmed that the fuzzy nucleosomes fall into the dynamic domain,...
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