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Tryptophan (Trp), an α‐amino acid, is the precursor of serotonin (5‐hydroxytryptamine, 5‐HT), which is involved in a variety of features of metabolic function and human nutrition. Evidence highlights the role of Trp metabolites (exclusively 5‐HT) in the gastrointestinal (GI) tract; however, the mechanisms of action involved in the release of 5‐HT in the GI tract are still unknown. Considering the...