Search results for: Mirja Ruutu

Items from 1 to 20 out of 25 results

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Clinical and prognostic significance of changes in haemoglobin concentration during 1 year of androgen‐deprivation therapy for hormone‐naïve bone‐metastatic prostate cancer

Maria Ebbinge, Anders Berglund, Eberhard Varenhorst, Per Olov Hedlund, more

Objective To estimate the strength of change in haemoglobin (Hb) concentrations during 1 year of androgen‐deprivation therapy (ADT) as a predictor of survival in hormone‐naïve patients with bone‐metastatic (Stage M1b) prostate cancer. Patients and Methods The patients included in this study were taken from the randomised trial (number 5) carried out by the Scandinavian Prostate Cancer Group (SPCG),...

article

Role of visual internal urethrotomy in pediatric urethral strictures

Ene Launonen, Jukka Sairanen, Mirja Ruutu, Seppo Taskinen

Journal of Pediatric Urology > 2014 > 10 > 3 > 545-549

To evaluate the efficiency of visual internal urethrotomies (VIUs) in pediatric patients.Thirty-four patients aged 0.2–16.3 years were treated with VIUs as a primary treatment for urethral stricture at our institution during 1980–2010. The stricture characteristics and need for repeat treatments as well as the results of repeat VIUs or dilatations were evaluated in a long-term follow-up.Each time...

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Active surveillance for small renal tumors: Have clinical concerns been addressed so far?

Paolo Gontero, Steven Joniau, Marco Oderda, Mirja Ruutu, more

International Journal of Urology > 20 > 4 > 356 - 361

The incidence of small renal masses is increasing, as a result of the wide adoption of imaging exams. Their management, however, is complicated, especially in patients with decreased life expectancy or comorbidities. Approximately 20% of small renal masses are benign and, even if malignant, just 10% show aggressive pathological features. Furthermore, competing cause mortality seems to exceed the cancer‐specific...

article

Contrasting DNA damage checkpoint responses in epithelium of the human seminal vesicle and prostate

Sari Jäämaa, Anna Sankila, Ville Rantanen, Karita Peltonen, more

The Prostate > 72 > 10 > 1060 - 1070

BACKGROUNDProstate and seminal vesicle are two similar hormone responsive human organs that differ dramatically in their cancer incidence. DNA damage response (DDR) is required for maintenance of genomic integrity. METHODSIn this study we investigated the DDR and cell cycle checkpoint activation of these organs using orthotopic cultures of human surgery‐derived tissues and primary cultures of isolated...

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Prostate cancer active surveillance and health‐related quality of life: results of the Finnish arm of the prospective trial

Hanna Vasarainen, Utku Lokman, Mirja Ruutu, Kimmo Taari, more

BJU International > 109 > 11 > 1614 - 1619

Study Type – Therapy (case series)Level of Evidence 4What's known on the subject? and What does the study add?Active surveillance is a management option in patients with localized prostate cancer. One concern is the possible psychological burden and quality‐of‐life effects caused by consciousness of living with untreated cancer. Previous studies have reported controversial results about the impact...

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The Impact of Interscreening Interval and Age on Prostate Cancer Screening With Prostate-Specific Antigen

Grace Hui-Min Wu, Anssi Auvinen, Amy Ming-Fang Yen, Matti Hakama, more

European Urology > 2012 > 61 > 5 > 1011-1018

Population-based screening for prostate cancer (PCa) has used serum prostate-specific antigen (PSA) since the early 1990s. However, the efficacy could be affected by screening interval, age ranges of screening, attendance, and contamination of the control group in randomised controlled trials.Assess the impact of the above-mentioned factors on screening efficacy.Parameters pertaining to the natural...

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Long-term quality-of-life outcomes after radical prostatectomy or watchful waiting: the Scandinavian Prostate Cancer Group-4 randomised trial

Eva Johansson, Gunnar Steineck, Lars Holmberg, Jan-Erik Johansson, more

The Lancet Oncology > 2011 > 12 > 9 > 891-899

For men with localised prostate cancer, surgery provides a survival benefit compared with watchful waiting. Treatments are associated with morbidity. Results for functional outcome and quality of life are rarely reported beyond 10 years and are lacking from randomised settings. We report results for quality of life for men in the Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) after a median...

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Inguinal Hernia After Radical Prostatectomy for Prostate Cancer: Results From a Randomized Setting and a Nonrandomized Setting

Johan Stranne, Eva Johansson, Andreas Nilsson, Anna Bill-Axelson, more

European Urology > 2010 > 58 > 5 > 719-726

Observational data indicate that retropubic radical prostatectomy (RRP) for prostate cancer (PCa) may induce inguinal hernia (IH) formation. Little is known about the influence of robot-assisted radical prostatectomy (RALP) on IH risk.To compare the incidence of IH after RRP and RALP to that of nonoperated patients with PCa and to a population control.We studied two groups. All 376 men included in...

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A Phase I/II Trial of Gefitinib Given Concurrently With Radiotherapy in Patients With Nonmetastatic Prostate Cancer

Greetta Joensuu, Timo Joensuu, Petri Nokisalmi, Chandana Reddy, more

International Journal of Radiation Oncology, Biology, Physics > 2010 > 78 > 1 > 42-49

To estimate the safety and tolerability of daily administration of 250 mg of gefitinib given concurrently with three-dimensional conformal radiotherapy for patients with nonmetastatic prostate cancer.A total of 42 patients with T2–T3N0M0 tumors were treated in a nonrandomized single-center study. A prostate-specific antigen (PSA) level of <20 and a good performance status (WHO, 0–1) were required...

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Results of the three rounds of the Finnish Prostate Cancer Screening Trial—The incidence of advanced cancer is decreased by screening

Tuomas P. Kilpeläinen, Anssi Auvinen, Liisa Määttänen, Paula Kujala, more

International Journal of Cancer > 127 > 7 > 1699 - 1705

Screening for prostate cancer (PC) remains a controversial issue despite some new evidence on the mortality benefits of PC screening. We conducted a prospective, randomized screening trial in Finland to investigate whether screening decreases PC incidence. Here, we report the incidence results from three screening rounds during a 12‐year period. Of the 80,144 men enrolled, 31,866 men were randomized...

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Why do men opt out of prostate‐cancer screening? Attitudes and perception among participants and non‐participants of a screening trial

Hanna Malmi, Mirja Ruutu, Liisa Määttänen, Ulf‐Håkan Stenman, more

BJU International > 106 > 4 > 472 - 477

Study Type – Decision analysis (patient preference) Level of Evidence 4 OBJECTIVETo evaluate attitudes to prostate cancer screening with prostate‐specific antigen (PSA) of men who complied with offered screening and those who declined it within the Finnish randomized population‐based screening trial, and to compare general health‐related quality of life (HRQL) between participants and non‐participants...

article

Prostate Cancer Mortality Reduction by Prostate-Specific Antigen–Based Screening Adjusted for Nonattendance and Contamination in the European Randomised Study of Screening for Prostate Cancer (ERSPC)

Monique J. Roobol, Melissa Kerkhof, Fritz H. Schröder, Jack Cuzick, more

European Urology > 2009 > 56 > 4 > 584-591

Prostate-specific antigen (PSA) based screening for prostate cancer (PCa) has been shown to reduce prostate specific mortality by 20% in an intention to screen (ITS) analysis in a randomised trial (European Randomised Study of Screening for Prostate Cancer [ERSPC]). This effect may be diluted by nonattendance in men randomised to the screening arm and contamination in men randomised to the control...

article

Re: Active Surveillance for the Management of Prostate Cancer in a Contemporary Cohort

Mirja Ruutu, Antti Rannikko

European Urology > 2009 > 55 > 1 > 244-245

article

Patient experience with hydrophilic catheters used in clean intermittent catheterization

Seppo Taskinen, Riitta Fagerholm, Mirja Ruutu

Journal of Pediatric Urology > 2008 > 4 > 5 > 367-371

To evaluate patient experience of hydrophilic catheters used for clean intermittent catheterization (CIC).Out of 107 consecutive patients on a CIC programme, 100 filled in a questionnaire concerning the hydrophilic catheters they were using for CIC.Sixty-four out of 100 patients were females and 83 had a neurogenic reason for CIC. The programme was started at median age 4 (range 0–32) years. The handling...

article

Diagnostic Value of Free Prostate-Specific Antigen among Men with a Prostate-Specific Antigen Level of <3.0μg per Liter

Patrik Finne, Anssi Auvinen, Liisa Määttänen, Teuvo L. Tammela, more

European Urology > 2008 > 54 > 2 > 362-370

The percentage of free prostate-specific antigen (%fPSA) improves the diagnostic accuracy for prostate cancer when the serum level of total PSA (tPSA) is elevated. Approximately 14% of men with a tPSA below 3μg/l have prostate cancer on biopsy, but the diagnostic value of %fPSA in such men is rather unknown. The purpose was to estimate the impact of %fPSA on future prostate cancer risk among men with...

article

Resection of Renal Cell Cancer Metastases: Where Do We Stand in 2008?

Mirja Ruutu, Petri Bono, Kimmo Taari

European Urology Supplements > 2008 > 7 > 5 > 436-442

Metastatic renal cell cancer is a highly malignant disease without established curative treatment. Nephrectomy for the primary tumour, whenever possible, is still regarded necessary because evidence suggests that it may lead to moderate survival benefit. Surgery for metastases can be debated but accumulated evidence from many studies, although retrospective in character, shows that aggressive removal...

article

Urinary Epidermal Growth Factor and Interleukin-6 Levels in Patients with Painful Bladder Syndrome/Interstitial Cystitis Treated with Cyclosporine or Pentosan Polysulfate Sodium

Jukka Sairanen, Kristina Hotakainen, Teuvo L.J. Tammela, Ulf-Håkan Stenman, more

Urology > 2008 > 71 > 4 > 630-633

To measure urinary epidermal growth factor (EGF) and interleukin-6 (IL-6) levels in painful bladder syndrome/interstitial cystitis (PBS/IC) patients randomized to either cyclosporine A (CyA) or pentosan polysulfate sodium (PPS) treatment for 6 months and compare the results with treatment response.Urine samples from PBS/IC patients were collected before (n = 37) and after treatment (n = 34). The concentration...

article

INCIDENCE OF ADVANCED PROSTATE CANCER IN THE FINNISH PROSTATE CANCER SCREENING TRIAL

Teuvo L Tammela, Paula Martikainen, Ulf-Hakan Stenman, Mirja Ruutu, more

The Journal of Urology > 2008 > 179 > 4 Supplement > 598

article

Clinically Overt Venous Thromboembolism after Urologic Cancer Surgery: Results from the @RISTOS Study

Roberto M. Scarpa, Giuseppe Carrieri, Gualberto Gussoni, Andrea Tubaro, more

European Urology > 2007 > 51 > 1 > 130-136

Incidence of venous thromboembolism (VTE) and need for thromboprophylaxis in urologic surgery have received little attention since only one randomised study has addressed this issue in the last 20 yr. The present prospective observational study evaluated incidence and risk factors for clinically overt VTE in a wide spectrum of consecutive patients undergoing surgery for cancer and compared findings...

article

Incidence and Follow-Up of Patients with Focal Prostate Carcinoma in 2 Screening Rounds After an Interval of 4 Years

Mirja Ruutu, Antti Rannikko

European Urology > 2006 > 49 > 2 > 411

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Search results for: Mirja Ruutu

Clinical and prognostic significance of changes in haemoglobin concentration during 1 year of androgen‐deprivation therapy for hormone‐naïve bone‐metastatic prostate cancer

Role of visual internal urethrotomy in pediatric urethral strictures

Active surveillance for small renal tumors: Have clinical concerns been addressed so far?

Contrasting DNA damage checkpoint responses in epithelium of the human seminal vesicle and prostate

Prostate cancer active surveillance and health‐related quality of life: results of the Finnish arm of the prospective trial

The Impact of Interscreening Interval and Age on Prostate Cancer Screening With Prostate-Specific Antigen

Long-term quality-of-life outcomes after radical prostatectomy or watchful waiting: the Scandinavian Prostate Cancer Group-4 randomised trial

Inguinal Hernia After Radical Prostatectomy for Prostate Cancer: Results From a Randomized Setting and a Nonrandomized Setting

A Phase I/II Trial of Gefitinib Given Concurrently With Radiotherapy in Patients With Nonmetastatic Prostate Cancer

Results of the three rounds of the Finnish Prostate Cancer Screening Trial—The incidence of advanced cancer is decreased by screening

Why do men opt out of prostate‐cancer screening? Attitudes and perception among participants and non‐participants of a screening trial

Prostate Cancer Mortality Reduction by Prostate-Specific Antigen–Based Screening Adjusted for Nonattendance and Contamination in the European Randomised Study of Screening for Prostate Cancer (ERSPC)

Re: Active Surveillance for the Management of Prostate Cancer in a Contemporary Cohort

Patient experience with hydrophilic catheters used in clean intermittent catheterization

Diagnostic Value of Free Prostate-Specific Antigen among Men with a Prostate-Specific Antigen Level of <3.0μg per Liter

Resection of Renal Cell Cancer Metastases: Where Do We Stand in 2008?

Urinary Epidermal Growth Factor and Interleukin-6 Levels in Patients with Painful Bladder Syndrome/Interstitial Cystitis Treated with Cyclosporine or Pentosan Polysulfate Sodium

INCIDENCE OF ADVANCED PROSTATE CANCER IN THE FINNISH PROSTATE CANCER SCREENING TRIAL

Clinically Overt Venous Thromboembolism after Urologic Cancer Surgery: Results from the @RISTOS Study

Incidence and Follow-Up of Patients with Focal Prostate Carcinoma in 2 Screening Rounds After an Interval of 4 Years

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