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Background
KIR3DL2, an inhibitory receptor expressed by natural killer cells and a subset of normal CD8+ T cells, is aberrantly expressed in neoplastic cells in transformed mycosis fungoides and Sézary syndrome. Anti‐KIR3DL2 targeted antibody therapy has shown potent activity in preclinical models for these diseases.
Objectives
To examine the expression of KIR3DL2 and its potential use as a therapeutic...
Phosphoantigens (PAgs) activate Vγ9Vδ2 T lymphocytes, inducing their potent and rapid response in vitro and in vivo. However, humans and nonhuman primates that receive repeated injections of PAgs progressively lose their Vγ9Vδ2 T cell response to them. To elucidate the molecular mechanisms of this in vivo desensitization, we analyzed the transcriptome of circulating Vγ9Vδ2 T cells from macaques injected...
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