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Microglia, the innate immune cells of the brain, develops a pro‐inflammatory, “primed” profile with age. Using single‐cell RNA‐sequencing, we confirmed hippocampal microglia of aged mice (18 m.o.) had an amplified (4 h) and prolonged (24 h) neuroinflammatory response to peripheral lipopolysaccharide (LPS) challenge compared to adults (2 m.o.). Overall, there were several unique cell‐, age‐, and time‐dependent...