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A total of 132 Streptococcus pneumoniae isolates collected between 2005 and 2006 in Japan were examined for susceptibility to telithromycin (TEL) and macrolide. The overall resistance to macrolide was 80%. Among the isolates, 128 strains had low‐level TEL susceptibility (minimal inhibitory concentrations [MICs] 0.03–1 μg mL−1), suggesting that pneumococci with reduced susceptibility to TEL have appeared...