Search results for: Mahmoud Rouabhia

Items from 1 to 20 out of 45 results

article

Enhancing Osteogenic Potential in Bone Tissue Engineering: Optimizing Pore Size in Alginate–Gelatin Composite Hydrogels

Zied Ferjaoui, Roberto López‐Muñoz, Soheil Akbari, Hawraa Issa, more

Advanced Engineering Materials > 26 > 13 > n/a - n/a

Bone tissue engineering relies on crucial scaffolds for tissue formation and stem cell differentiation. A composite scaffold of alginate‐gelatin effectively supports these processes. This study aims to design a porous alginate‐gelatin hydrogel and assess pore size effects on cell behavior, focusing on morphology, adhesion, and proliferation in distinct osteogenic environments. Hydrogels are prepared...

article

A novel foaming technique to develop functional open‐cell polylactic acid scaffolds for bone tissue engineering

Miada Abubaker Osman, Nick Virgilio, Mahmoud Rouabhia, Louis‐Etienne Lorenzo, more

Journal of Applied Polymer Science > 140 > 32 > n/a - n/a

The aim of this study was to develop a solvent‐free polylactic acid (PLA) open‐cell porous scaffold for bone tissue engineering using compression molding and a new chemical foaming compound, that we named CFCO. The latter is composed of a blend of PLA and azodicarbonamide (ADA) as a chemical foaming agent, with the addition of chitosan‐grafted PLA (CS‐g‐PLA) copolymer at various concentrations. The...

article

Electrical stimulation promotes the wound‐healing properties of diabetic human skin fibroblasts

Atieh Abedin‐Do, Ze Zhang, Yvan Douville, Mireille Méthot, more

Journal of Tissue Engineering and Regenerative Medicine > 16 > 7 > 643 - 652

This study evaluated the effect of low (20 and 40 mV/mm) intensities of electrical stimulation on the proliferation and migration of skin fibroblasts from diabetic donors. We also examined the effect of electrical stimulation on modulating the capacity of fibroblasts to contract collagen gel, express alpha‐smooth muscle actin, and secrete proteolytic enzymes involved in regulating extracellular matrix...

article

Electronic cigarette vapor increases Streptococcus mutans growth, adhesion, biofilm formation, and expression of the biofilm‐associated genes

Mahmoud Rouabhia, Abdelhabib Semlali

Oral Diseases > 27 > 3 > 639 - 647

Objective It still not known whether electronic cigarettes (e‐cigarettes) contribute to dental caries. This study aimed to evaluate the effect of e‐cigarettes on the growth of Streptococcus mutans, the formation of biofilm, and the expression of certain virulence genes. Materials and Methods Streptococcus mutans cells were exposed or not to e‐cigarettes with and without nicotine or to cigarette...

article

Electrical stimulation promotes the proliferation of human keratinocytes, increases the production of keratin 5 and 14, and increases the phosphorylation of ERK1/2 and p38 MAP kinases

Mahmoud Rouabhia, Hyun Jin Park, Atieh Abedin‐Do, Yvan Douville, more

Journal of Tissue Engineering and Regenerative Medicine > 14 > 7 > 909 - 919

Effective wound healing remains a significant clinical challenge in reducing patient morbidity and improving quality of life. Wound healing is a complex process involving the endogenous electrical field. The electrical field can contribute to wound healing by activating keratinocytes to promote reepithelialization. The objective of this study was to determine the effects of exogenous electrical stimulation...

article

Surface treatment with amino acids of porous collagen based scaffolds to improve cell adhesion and proliferation

Mahmoud Rouabhia, Nabila Mighri, Jifu Mao, Hyun Jin Park, more

The Canadian Journal of Chemical Engineering > 96 > 10 > 2236 - 2242

The purpose of this study was to improve the biocompatibility of glutaraldehyde (GA) cross‐linked chitosan coated collagen scaffold for cartilage tissue regeneration. In order to prevent the potential toxicity of GA, we treated the designed scaffold with either glutamic acid or glycine. Amino acid treated scaffolds were characterized by scanning electron microscopy (SEM) techniques. Afterward, chondrocyte...

article

Comparative study of the effects of cigarette smoke and electronic cigarettes on human gingival fibroblast proliferation, migration and apoptosis

Humidah Alanazi, Hyun Jin Park, Jamila Chakir, Abdelhabib Semlali, more

Food and Chemical Toxicology > 2018 > 118 > C > 390-398

In an effort to reduce smoking-related diseases, alternative products such as e-cigarettes have been proposed. However, despite their growing popularity, the potential toxicity of e-cigarettes remains largely unknown. In this study, human gingival fibroblasts were repeatedly exposed to cigarette smoke condensate (CSC) and to nicotine-rich (NR) or nicotine-free (NF) e-vapor condensates for 60 min once...

article

A shift in the IL-6/STAT3 signalling pathway imbalance towards the SHP2 pathway in severe asthma results in reduced proliferation process

Ikhlass Haj Salem, Sophie Plante, Abdelilah S. Gounni, Mahmoud Rouabhia, more

Cellular Signalling > 2018 > 43 > C > 47-54

Bronchial fibroblasts are the main structural cells responsible for extracellular matrix production and turnover in lung tissue. They play a key role in airway remodelling in asthma through different cytokines including interleukin (IL-6).To decipher IL-6 signalling in bronchial fibroblasts obtained from severe eosinophilic asthmatics compared to mild asthmatics and healthy controls.Human bronchial...

article

Effect of soft foods on primary human gingival epithelial cell growth and the wound healing process

Mahmoud Rouabhia, Dounia Rouabhia, Hyun Jin Park, Luc Giasson, more

Food Research International > 2017 > 100 > P1 > 433-441

Investigate the effect of soft diet foods on gingival epithelial cell growth, migration, and mediator secretion.Human gingival epithelial cells were stimulated for various time periods with the following soft diet foods: orange juice, drinkable yogurt, and a nutritional drink. Cell growth was determined by an MTT assay and cell migration was investigated by a scratch assay and F-actin filament staining...

article

Antimicrobial peptide KSL-W promotes gingival fibroblast healing properties in vitro

Hyun-Jin Park, Mabrouka Salem, Abdelhabib Semlali, Kai P Leung, more

Peptides > 2017 > 93 > C > 33-43

We investigated the effect of synthetic antimicrobial decapeptide KSL-W (KKVVFWVKFK) on normal human gingival fibroblast growth, migration, collagen gel contraction, and α-smooth muscle actin protein expression. Results show that in addition to promoting fibroblast adhesion by increasing F-actin production, peptide KSL-W promoted cell growth by increasing the S and G2/M cell cycle phases, and enhanced...

article

Pulsed electrical stimulation modulates fibroblasts' behaviour through the Smad signalling pathway

Yongliang Wang, Mahmoud Rouabhia, Denis Lavertu, Ze Zhang

Journal of Tissue Engineering and Regenerative Medicine > 11 > 4 > 1110 - 1121

The aim of this study was to investigate the healing characteristics and the underlying signalling pathway of human dermal fibroblasts under the influence of pulsed electrical stimulation (PES). Primary human dermal fibroblasts were seeded on polypyrrole‐coated polyester fabrics and subjected to four different PES protocols. The parameters of the rectangular pulse included potential intensity (50...

article

E‐Cigarette Vapor Induces an Apoptotic Response in Human Gingival Epithelial Cells Through the Caspase‐3 Pathway

Mahmoud Rouabhia, Hyun Jin Park, Abdelhabib Semlali, Andrew Zakrzewski, more

Journal of Cellular Physiology > 232 > 6 > 1539 - 1547

Electronic cigarettes represent an increasingly significant proportion of today's consumable tobacco products. E‐cigarettes contain several chemicals which may promote oral diseases. The aim of this study was to investigate the effect of e‐cigarette vapor on human gingival epithelial cells. Results show that e‐cigarette vapor altered the morphology of cells from small cuboidal form to large undefined...

article

Pulsed electrical stimulation benefits wound healing by activating skin fibroblasts through the TGFβ1/ERK/NF-κB axis

Yongliang Wang, Mahmoud Rouabhia, Ze Zhang

Biochimica et Biophysica Acta (BBA) - General Subjects > 2016 > 1860 > 7 > 1551-1559

Dermal fibroblasts activated by conductive polymer-mediated electrical stimulation (ES) have shown myofibroblast characteristics that favor wound healing. However, the signaling pathway related to this phenotype switch remains unclear, and the in vivo survival of the electrically activated cells has never been studied.Primary human skin fibroblasts were exposed to pulsed-ES mediated through polypyrrole...

article

Electrically Activated Primary Human Fibroblasts Improve In Vitro and In Vivo Skin Regeneration

Mahmoud Rouabhia, Hyun Jin Park, Ze Zhang

Journal of Cellular Physiology > 231 > 8 > 1814 - 1821

Electrical stimulation (ES) changes cellular behaviors and thus constitutes a potential strategy to promote wound healing. However, well‐controlled in vitro findings have yet to be translated to in vivo trials. This study was to demonstrate the feasibility and advantages of transplanting electrically activated cells (E‐Cells) to help wound healing. Primary human skin fibroblasts were activated through...

article

Ex Vivo Assay of Electrical Stimulation to Rat Sciatic Nerves: Cell Behaviors and Growth Factor Expression

Zhiyong Du, Olexandr Bondarenko, Dingkun Wang, Mahmoud Rouabhia, more

Journal of Cellular Physiology > 231 > 6 > 1301 - 1312

Neurite outgrowth and axon regeneration are known to benefit from electrical stimulation. However, how neuritis and their surroundings react to electrical field is difficult to replicate by monolayer cell culture. In this work freshly harvested rat sciatic nerves were cultured and exposed to two types of electrical field, after which time the nerve tissues were immunohistologically stained and the...

article

Cigarette smoke condensate increases C. albicans adhesion, growth, biofilm formation, and EAP1 , HWP1 and SAP2 gene expression

Abdelhabib Semlali, Kerstin Killer, Humidah Alanazi, Witold Chmielewski, more

BMC Microbiology > 2014 > 14 > 1 > 1-9

Background Smokers are more prone to oral infections than are non-smokers. Cigarette smoke reaches the host cells but also microorganisms present in the oral cavity. The contact between cigarette smoke and oral bacteria promotes such oral diseases as periodontitis. Cigarette smoke can also modulate C. albicans activities that promote oral candidiasis. The goal of this study...

article

Electrical stimulation modulates osteoblast proliferation and bone protein production through heparin‐bioactivated conductive scaffolds

Shiyun Meng, Mahmoud Rouabhia, Ze Zhang

Bioelectromagnetics > 34 > 3 > 189 - 199

Electrical fields are known to interact with human cells. This principle has been explored to regulate cellular activities for bone tissue regeneration. In this work, Saos‐2 cells were cultured on conductive scaffolds made of biodegradable poly(L‐lactide) and the heparin‐containing, electrically conducting polypyrrole (PPy/HE) to study their reaction to electrical stimulation (ES) mediated through...

article

Antagonistic effect of Candida albicans and IFNγ on E-cadherin expression and production by human primary gingival epithelial cells

Mahmoud Rouabhia, Abdelhabib Semlali, Julie Audoy, Witold Chmielewski

Cellular Immunology > 2012 > 280 > 1 > 61-67

Caused mainly by Candida albicans, oropharyngeal candidiasis is the most common oral complication associated with HIV disease worldwide. Host defenses against C. albicans essentially fall into two categories: specific immune mechanisms and local oral mucosal epithelial cell defenses. Since oral mucosa is the first line of defense in the form of a physical barrier against C. albicans invasion, and...

article

Hydroxyapatite bioactivated bacterial cellulose promotes osteoblast growth and the formation of bone nodules

Neftaha Tazi, Ze Zhang, Younès Messaddeq, Luciana Almeida-Lopes, more

AMB Express > 2012 > 2 > 1 > 1-10

The goal of this study was to investigate the feasibility of bacterial cellulose (BC) scaffold to support osteoblast growth and bone formation. BC was produced by culturing Acetobacter xylinum supplemented with hydroxyapatite (HA) to form BC membranes (without HA) and BC/HA membranes. Membranes were subjected to X-ray photoelectron spectroscopy (XPS) analysis to determine surface element composition...

article

Effect of periodontopathogen lipopolysaccharides and proinflammatory cytokines on CD46, CD55, and CD59 gene/protein expression by oral epithelial cells

Hayette Mahtout, Sèverine Curt, Fatiha Chandad, Mahmoud Rouabhia, more

FEMS Immunology & Medical Microbiology > 62 > 3 > 295 - 303

Membrane‐anchored complement regulatory proteins (CRPs), including CD46, CD55, and CD59, protect host cells from complement attack. In the present study, we investigated whether periodontopathogen lipopolysaccharide and proinflammatory cytokines modulate CRP gene/protein expression in human oral epithelial cells. The lipopolysaccharide of Treponema denticola and Tannerella forsythia were the most...

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INFONA - science communication portal

Search results for: Mahmoud Rouabhia

Enhancing Osteogenic Potential in Bone Tissue Engineering: Optimizing Pore Size in Alginate–Gelatin Composite Hydrogels

A novel foaming technique to develop functional open‐cell polylactic acid scaffolds for bone tissue engineering

Electrical stimulation promotes the wound‐healing properties of diabetic human skin fibroblasts

Electronic cigarette vapor increases Streptococcus mutans growth, adhesion, biofilm formation, and expression of the biofilm‐associated genes

Electrical stimulation promotes the proliferation of human keratinocytes, increases the production of keratin 5 and 14, and increases the phosphorylation of ERK1/2 and p38 MAP kinases

Surface treatment with amino acids of porous collagen based scaffolds to improve cell adhesion and proliferation

Comparative study of the effects of cigarette smoke and electronic cigarettes on human gingival fibroblast proliferation, migration and apoptosis

A shift in the IL-6/STAT3 signalling pathway imbalance towards the SHP2 pathway in severe asthma results in reduced proliferation process

Effect of soft foods on primary human gingival epithelial cell growth and the wound healing process

Antimicrobial peptide KSL-W promotes gingival fibroblast healing properties in vitro

Pulsed electrical stimulation modulates fibroblasts' behaviour through the Smad signalling pathway

E‐Cigarette Vapor Induces an Apoptotic Response in Human Gingival Epithelial Cells Through the Caspase‐3 Pathway

Pulsed electrical stimulation benefits wound healing by activating skin fibroblasts through the TGFβ1/ERK/NF-κB axis

Electrically Activated Primary Human Fibroblasts Improve In Vitro and In Vivo Skin Regeneration

Ex Vivo Assay of Electrical Stimulation to Rat Sciatic Nerves: Cell Behaviors and Growth Factor Expression

Cigarette smoke condensate increases C. albicans adhesion, growth, biofilm formation, and EAP1 , HWP1 and SAP2 gene expression

Electrical stimulation modulates osteoblast proliferation and bone protein production through heparin‐bioactivated conductive scaffolds

Antagonistic effect of Candida albicans and IFNγ on E-cadherin expression and production by human primary gingival epithelial cells

Hydroxyapatite bioactivated bacterial cellulose promotes osteoblast growth and the formation of bone nodules

Effect of periodontopathogen lipopolysaccharides and proinflammatory cytokines on CD46, CD55, and CD59 gene/protein expression by oral epithelial cells

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