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Notch receptor activation is regulated by the intramembrane protease γ‐secretase, which cleaves and liberates the Notch intracellular domain (Nicd) that regulates gene transcription. While γ‐secretase cleavage is necessary, we demonstrate it is insufficient for Notch activation and requires vesicular trafficking. Here, we report Divalent metal transporter 1 (Dmt1, Slc11A2) as a novel and essential...
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