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TEAD transcription factors play a central role in the Hippo signaling pathway. In this study, we focused on transcriptional enhancer factor TEF‐3 (TEAD4), exploring its regulation by the deubiquitinase OTU domain‐containing protein 6A (OTUD6A). We identified OTUD6A as a TEAD4‐interacting deubiquitinase, positively influencing TEAD‐driven transcription without altering TEAD4 stability. Structural analyses...