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Great advancements have been made in understanding the basic mechanisms of ictogenesis using single‐cell electrophysiology (e.g., patch clamp, sharp electrode), large‐scale electrophysiology (e.g., electroencephalography [EEG], field potential recording), and large‐scale imaging (magnetic resonance imaging [MRI], positron emission tomography [PET], calcium imaging of acetoxymethyl ester [AM] dye‐loaded...
The transformation of dendritic excitatory synaptic inputs to axonal action potential output is the fundamental computation performed by all principal neurons. We show that in the hippocampus this transformation is potently controlled by recurrent inhibitory microcircuits. However, excitatory input on highly excitable dendritic branches could resist inhibitory control by generating strong dendritic...
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