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Regulatory T (Treg) lymphocytes play a central role in the control of autoimmune pathology. Any alteration in Treg‐cell biology in mouse strains used for the study of these disorders therefore raises the question of its direct link with disease susceptibility. Paradoxically, in non‐obese diabetic (NOD) mice increased numbers of Treg cells develop in the thymus. In this report we identify a locus of...