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Purinergic signaling and associated ectonucleotidases, such as CD39 and CD73, have been implicated in the pathogenesis of inflammatory bowel disease (IBD). CD39 is known to be a Treg memory cell marker, and here we determine the phenotype and function of CD73+CD4+T lymphocytes in patients with IBD. We describe elevated levels of CD73+CD4+T cells in the peripheral blood and intestinal lamina propria...