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BACKGROUND:Columnar cell lesions are frequently associated with atypical ductal hyperplasia, lobular neoplasia, and tubular carcinoma, and have been suggested as a precursor lesion for low‐grade carcinomas. However, in long‐term follow‐up studies, columnar cell lesions are associated with only a slight increase in later breast cancer development. If columnar cell lesions are precursor lesions, one...
BACKGROUND:Protein phosphatase 2A (PP2A) is a major cellular phosphatase and plays key regulatory roles in growth, differentiation, and apoptosis. Women who are diagnosed with benign proliferative breast disease are at increased risk for the subsequent development of breast cancer.
METHODS:The authors evaluated genetic variation of PP2A holoenzyme subunits for their potential contribution to breast...
Clinical decisions about atypical lobular hyperplasia are based on the belief that later invasive breast-cancer risk is equal in both breasts. We aimed to show laterality and subsequent risk implications of invasive breast cancer in women with atypical lobular hyperplasia. We did a retrospective cohort study of 252 women who had undergone 261 benign surgical biopsies that showed atypical lobular...
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