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A CA‐repeat microsatellite in insulin‐like growth factor 1 (IGF1) promoter was associated with interindividual variation of circulating IGF1 level. Previously, we reported that such association was due to variation of haplotype unit in a linkage disequilibrium block composed of microsatellite and single‐nucleotide polymorphisms (SNPs), suggesting the presence of an interaction between them. In this...
Objective Systemic insulin‐like growth factor 1 (IGF1) level is an important risk factor for various diseases. The inter‐individual variation of serum IGF1 is determined by environmental and genetic factors, which are attributed to a microsatellite in IGF1 promoter. However, the exact nature of the underlying regulatory elements accounting for this association has not been characterized. Here, we...
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