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Front Cover. In the quest for alternative therapies to treat leishmaniasis and schistosomiasis, two of the main Neglected Tropical Diseases, the screening of synthetic natural product‐inspired compounds emerges as a viable strategy. In the light of the antiparasitic effects of natural prenylated p‐coumaric acid derivatives like artepillin C, a phenylpropanoid sourced from Brazilian green propolis,...
We have evaluated eight p‐coumaric acid prenylated derivatives in vitro for their antileishmanial activity against Leishmania amazonensis promastigotes and their antischistosomal activity against Schistosoma mansoni adult worms. Compound 7 ((E)‐3,4‐diprenyl‐4‐isoprenyloxycinnamic alcohol) was the most active against L. amazonensis (IC50=45.92 μM) and S. mansoni (IC50=64.25 μM). Data indicated that...
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