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Background and Purpose
As the only ionotropic receptor in the 5‐HT receptor family, the 5‐HT3 receptor (5‐HT3R) is involved in psychiatric disorders and its modulators have potential therapeutic effects for cognitive impairment in these disorders. However, it remains unclear how 5‐HT3Rs shape synaptic plasticity for memory function.
Experimental Approach
Extracellular as well as whole‐cell electrophysiological...