Search results for: Thais Souto‐Padron

Items from 1 to 20 out of 29 results

article

LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL

Daniel Prieto, Noé Seija, Angimar Uriepero, Thais Souto‐Padron, more

British Journal of Haematology > 182 > 4 > 521 - 525

Lipoprotein lipase (LPL) mRNA expression in chronic lymphocytic leukaemia (CLL) is associated with an unmutated immunoglobulin profile and poor clinical outcome. We evaluated the subcellular localization of LPL protein in CLL cells that did or did not express LPL mRNA. Our results show that LPL protein is differently located in CLL cells depending on whether it is incorporated from the extracellular...

article

Triatoma infestans relies on salivary lysophosphatidylcholine to enhance Trypanosoma cruzi transmission

Michele Souza Lima, Alan Brito Carneiro, Thaís Souto-Padron, José Jurberg, more

Acta Tropica > 2018 > 178 > C > 68-72

Triatoma infestans is a mandatory haematophagous vector of Chagas disease in Brazil. Despite a large number of studies on the anti-haemostatic molecules present in its saliva, the role of its salivary components on parasite transmission is poorly understood. Here, we show that the bioactive lipid molecule, lysophosphatidylcholine (LPC), is present in the salivary gland of T. infestans. We characterized...

article

Antiproliferative and ultrastructural effects of phenethylamine derivatives on promastigotes and amastigotes of Leishmania (Leishmania) infantum chagasi

Paula Ferreira Brasil, Júlia Araújo de Freitas, Anna Léa Silva Barreto, Camila Marques Adade, more

Parasitology International > 2017 > 66 > 2 > 47-55

Leishmania (Leishmania) infantum chagasi is one of the agents that cause visceral leishmaniasis. This disease occurs more frequently in third world countries, such as Brazil. The treatment is arduous, and is dependent on just a few drugs like the antimonial derivatives and amphotericin B. Moreover, these drugs are not only expensive, but they can also cause severe side effects and require long-term...

article

Phenotypic and Genotypic Characterization of Biofilm Formation in Staphylococcus haemolyticus

Elaine M. Barros, Moara Lemos, Thais Souto-Padrón, Marcia Giambiagi-deMarval

Current Microbiology > 2015 > 70 > 6 > 829-834

Staphylococcus haemolyticus is one of the most frequently isolated coagulase-negative staphylococci. The ability to produce biofilm has contributed to its emergence as a nosocomial pathogen. In this study, some growth conditions were tested to determine their influence on biofilm formation. Brain–heart infusion (BHI) broth containing glucose was used to screen 64 clinical strains. A strong...

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Phylogenetic and morphological characterization of trypanosomes from Brazilian armoured catfishes and leeches reveal high species diversity, mixed infections and a new fish trypanosome species

Moara Lemos, Bruno R. Fermino, Cíntia Simas-Rodrigues, Luísa Hoffmann, more

Parasites & Vectors > 2015 > 8 > 1 > 1-17

Background Several Trypanosoma species transmitted by leeches infect marine and freshwater fish worldwide. To date, all South American fish trypanosome species identified have been based on unreliable morphological parameters. We recently isolated and cultured trypanosomes from the Brazilian armoured catfishes Hypostomus luetkeni and H. affinis. Here, we report the first phylogenetic analyses of South...

article

Effect of the secretory leucocyte proteinase inhibitor (SLPI) on Candida albicans biological processes: A therapeutic alternative?

José Alexandre da Rocha Curvelo, Anna Léa Silva Barreto, Maristela Barbosa Portela, Daniela Sales Alviano, more

Archives of Oral Biology > 2014 > 59 > 9 > 928-937

The aim of this study was to evaluate the effect of SLPI on the growth and biological processes of Candida albicans.Two C. albicans strains were used in this study, a clinical isolate resistant to fluconazole (PRI) and a reference strain ATCC 24433. The minimal inhibitory concentration (MIC) was determined according to the CLSI methodology. The influence of SLPI on secreted serine proteinase activities...

article

Trypanosoma cruzi-secreted vesicles have acid and alkaline phosphatase activities capable of increasing parasite adhesion and infection

Roberta F. C. Neves, Anne C. S Fernandes, José R Meyer-Fernandes, Thais Souto-Padrón

Parasitology Research > 2014 > 113 > 8 > 2961-2972

Trypanosoma cruzi virulence factors include molecules expressed on the cell surface as well as those secreted or shed into the extracellular medium. Phosphatase activities modulate different aspects of T. cruzi infection, although no studies to date addressed the presence and activity of phosphatases in vesicles secreted by this parasite. Here, we characterized acidic and alkaline secreted phosphatase...

article

Extracellular vesicles shed by Trypanosoma cruzi are linked to small RNA pathways, life cycle regulation, and susceptibility to infection of mammalian cells

Maria R. Garcia-Silva, Roberta Ferreira Cura das Neves, Florencia Cabrera-Cabrera, Julia Sanguinetti, more

Parasitology Research > 2014 > 113 > 1 > 285-304

The protozoan parasite Trypanosoma cruzi has a complex life cycle characterized by intracellular and extracellular forms alternating between invertebrate and mammals. To cope with these changing environments, T. cruzi undergoes rapid changes in gene expression, which are achieved essentially at the posttranscriptional level. At present, expanding families of small RNAs are recognized as key players...

article

Melittin peptide kills Trypanosoma cruzi parasites by inducing different cell death pathways

Camila M. Adade, Isabelle R.S. Oliveira, Joana A.R. Pais, Thaïs Souto-Padrón

Toxicon > 2013 > 69 > Complete > 227-239

Antimicrobial peptides (AMPs) are components of the innate immune response that represent desirable alternatives to conventional pharmaceuticals, as they have a fast mode of action, a low likelihood of resistance development and can act in conjunction with existing drug regimens. AMPs exhibit strong inhibitory activity against both Gram-positive and Gram-negative bacteria, fungi, viruses, metazoans...

article

Different secreted phosphatase activities in Leishmania amazonensis

Anne C.S. Fernandes, Deivid C. Soares, Elvira M. Saraiva, José R. Meyer‐Fernandes, more

FEMS Microbiology Letters > 340 > 2 > 117 - 128

Leishmania has strong acid phosphatase activity on the external surface of the plasma membrane and secreted into the extracellular milieu. Secreted acid phosphatase (sAcP), which is the most abundant secreted protein of Leishmania, is also a virulence factor that plays a role in vertebrate infection and survival in sand flies. In this study, we characterized the secreted phosphatase activities in...

article

43. Melittin Peptide Kills Trypanosoma cruzi Epimastigotes and Trypomastigotes Forms by Different Cell Death Phenotypes

Camila M. Adade, Isabelle Ribeiro, Joana Pais, Thais Souto-Padrón

Toxicon > 2012 > 60 > 2 > 116

article

44. Leishmanicidal Effects of a Phospholipase A2 Isolated from Crotalus viridis viridis Snake Venom

Camila M. Adade, S. Fernandes Anne Cristine, O. Carvalho Ana Lúcia, Russolina B. Zingali, more

Toxicon > 2012 > 60 > 2 > 117

article

Differential collagenolytic activity of Candida albicans isolated from oral mucosa and dentinal carious lesions of HIV-infected children

Maristela Barbosa Portela, Madeleine Souza das Chagas, Daniella Ferreira Cerqueira, Ivete Pomarico Ribeiro de Souza, more

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology > 2012 > 113 > 3 > 378-383

The aim of this study was to compare type I collagen degradation by Candida albicans isolated from oral mucosa (M) and cavitated active dentinal caries (CAD) of HIV-infected children. To verify the proteolytic activity, the specimens were cultivated in brain-heart infusion medium and the supernatants were incubated in the presence or absence of type I collagen at 37°C for 12 hours and analyzed...

article

SP600125 inhibits Orthopoxviruses replication in a JNK1/2 -independent manner: Implication as a potential antipoxviral

Anna C.T.C. Pereira, Jamária A.P. Soares-Martins, Flávia G.G. Leite, André F.P. Da Cruz, more

Antiviral Research > 2012 > 93 > 1 > 69-77

The pharmacological inhibitor SP600125 [anthra(1,9-cd)pyrazol-6(2H)-one 1,9-pyrazoloanthrone] has been largely employed as a c-JUN N-terminal kinase (JNK1/2) inhibitor. In this study, we evaluated whether pretreatment with SP600125 was able to prevent Orthopoxviruses Vaccinia virus (VACV), Cowpox virus (CPXV) and modified Vaccinia virus Ankara (MVA) replication. We found that incubation with SP600125...

article

Production of an antimicrobial substance against Cryptococcus neoformans by Paenibacillus brasilensis Sa3 isolated from the rhizosphere of Kalanchoe brasiliensis

Tiago Oliveira Fortes, Daniela Sales Alviano, Gleiser Tupinambá, Thaís Souto Padrón, more

Microbiological Research > 2008 > 163 > 2 > 200-207

An antifungal substance produced by Paenibacillus brasilensis strain Sa3 was preliminary characterized and showed to be stable after treatment with different enzymes and organic solvents and at a wide range of pH, and presented a molecular weight between 3 and 10kDa. In vitro antagonism of this strain towards Cryptococcus neoformans was investigated by optical and electronic microscopic analyses and...

article

In vitro effects of suramin on Trypanosoma cruzi

Danielle Frias Ribeiro Bisaggio, Camila Marques Adade, Thaïs Souto-Padrón

International Journal of Antimicrobial Agents > 2008 > 31 > 3 > 282-286

Suramin has been previously reported to inhibit distinct cellular enzymes and to affect the synthesis and distribution of cytoskeleton proteins, cell differentiation and proliferation. The present study indicates that prolonged incubation of Trypanosoma cruzi-infected cells in the presence of 500μM suramin during intracellular development of the parasite causes morphological changes in amastigote...

article

Mycelial forms of Pseudallescheria boydii present ectophosphatase activities

Tina Kiffer-Moreira, Ana Acacia S. Pinheiro, Márcia R. Pinto, Fabiano F. Esteves, more

Archives of Microbiology > 2007 > 188 > 2 > 159-166

Phosphatase activities were characterized in intact mycelial forms of Pseudallescheria boydii, which are able to hydrolyze the artificial substrate p-nitrophenylphosphate (p-NPP) to p-nitrophenol (p-NP) at a rate of 41.41 ± 2.33 nmol p-NP per h per mg dry weight, linearly with increasing time and with increasing cell density. MgCl₂, MnCl₂ and ZnCl₂ were able to increase the (p-NPP) hydrolysis while...

article

Effect of suramin on trypomastigote forms of Trypanosoma cruzi: Changes on cell motility and on the ultrastructure of the flagellum-cell body attachment region

Danielle F.R. Bisaggio, Loraine Campanati, Rodrigo C.V. Pinto, Thaïs Souto-Padrón

Acta Tropica > 2006 > 98 > 2 > 162-175

Suramin has been previously reported to inhibit distinct cell enzymes and to affect the synthesis and distribution of cytoskeleton proteins. Our study indicates that prolonged incubation of Trypanosoma cruzi infected-LLC-MK ₂ cells in the presence of 500μM suramin during the intracellular development of the parasite caused morphological changes on trypomastigote forms characterized by a partial...

article

Heterogeneous resistance to vancomycin in Staphylococcus epidermidis, Staphylococcus haemolyticus and Staphylococcus warneri clinical strains: characterisation of glycopeptide susceptibility profiles and cell wall thickening

Ana Paula Ferreira Nunes, Lúcia Martins Teixeira, Natália Lopes Pontes Iorio, Carla Callegário Reis Bastos, more

International Journal of Antimicrobial Agents > 2006 > 27 > 4 > 307-315

The population analysis profile (PAP) method as well as analysis of autolytic activity and cellular ultrastructure by transmission electron microscopy (TEM) were used to characterise Staphylococcus epidermidis, Staphylococcus haemolyticus and Staphylococcus warneri clinical strains with reduced susceptibility to glycopeptides. All strains showed heterogeneous profiles to vancomycin and teicoplanin...

article

Biological aspects of the Trypanosoma cruzi (Dm28c clone) intermediate form, between epimastigote and trypomastigote, obtained in modified liver infusion tryptose (LIT) medium

Saulo C. Bourguignon, Cicero B. Mello, Dilvani O. Santos, Marcelo S. Gonzalez, more

Acta Tropica > 2006 > 98 > 1 > 103-109

We describe some biological characteristics of the Trypanosoma cruzi intermediate form derived from the transformation of epimastigotes to trypomastigotes obtained from cultivation in modified liver infusion tryptose (LIT) medium. The ultrastructural analysis of the intermediate forms in this medium showed the enlargement of the kinetoplast located adjacent to the flagellate nucleus. Some biological...

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Search results for: Thais Souto‐Padron

LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL

Triatoma infestans relies on salivary lysophosphatidylcholine to enhance Trypanosoma cruzi transmission

Antiproliferative and ultrastructural effects of phenethylamine derivatives on promastigotes and amastigotes of Leishmania (Leishmania) infantum chagasi

Phenotypic and Genotypic Characterization of Biofilm Formation in Staphylococcus haemolyticus

Phylogenetic and morphological characterization of trypanosomes from Brazilian armoured catfishes and leeches reveal high species diversity, mixed infections and a new fish trypanosome species

Effect of the secretory leucocyte proteinase inhibitor (SLPI) on Candida albicans biological processes: A therapeutic alternative?

Trypanosoma cruzi-secreted vesicles have acid and alkaline phosphatase activities capable of increasing parasite adhesion and infection

Extracellular vesicles shed by Trypanosoma cruzi are linked to small RNA pathways, life cycle regulation, and susceptibility to infection of mammalian cells

Melittin peptide kills Trypanosoma cruzi parasites by inducing different cell death pathways

Different secreted phosphatase activities in Leishmania amazonensis

43. Melittin Peptide Kills Trypanosoma cruzi Epimastigotes and Trypomastigotes Forms by Different Cell Death Phenotypes

44. Leishmanicidal Effects of a Phospholipase A2 Isolated from Crotalus viridis viridis Snake Venom

Differential collagenolytic activity of Candida albicans isolated from oral mucosa and dentinal carious lesions of HIV-infected children

SP600125 inhibits Orthopoxviruses replication in a JNK1/2 -independent manner: Implication as a potential antipoxviral

Production of an antimicrobial substance against Cryptococcus neoformans by Paenibacillus brasilensis Sa3 isolated from the rhizosphere of Kalanchoe brasiliensis

In vitro effects of suramin on Trypanosoma cruzi

Mycelial forms of Pseudallescheria boydii present ectophosphatase activities

Effect of suramin on trypomastigote forms of Trypanosoma cruzi: Changes on cell motility and on the ultrastructure of the flagellum-cell body attachment region

Heterogeneous resistance to vancomycin in Staphylococcus epidermidis, Staphylococcus haemolyticus and Staphylococcus warneri clinical strains: characterisation of glycopeptide susceptibility profiles and cell wall thickening

Biological aspects of the Trypanosoma cruzi (Dm28c clone) intermediate form, between epimastigote and trypomastigote, obtained in modified liver infusion tryptose (LIT) medium

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