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Hepatocyte‐like cells derived from human‐induced pluripotent stem cells (hiPSC‐HLC) are expected to have important applications in drug screening and regenerative medicine. However, hiPSC‐HLC are difficult to produce on a large‐scale to obtain relevant numbers for such applications. The aim of this study was to implement a novel integrated strategy for scalable production of hiPSC‐HLC and demonstrate...
Iron (Fe) is essential to almost all organisms, as required by cells to satisfy metabolic needs and accomplish specialized functions. Its ability to exchange electrons between different substrates, however, renders it potentially toxic. Fine tune‐mechanisms are necessary to maintain Fe homeostasis and, as such, to prevent its participation into the Fenton reaction and generation of oxidative stress...
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