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In the search for new intermediates for heterocyclic synthesis, the reactivity of 6‐iminophosphoranepyrimidines against dimethyl acetylenedicarboxylate (DMAD) and ethyl propiolate as dienophiles, was studied in this work. The presence of a viable 2‐azadienic moiety in pyrimidin‐4‐one rings (oxo derivatives) favored reaction of DMAD by [4 + 2]/retro‐[4 + 2] sequence, in addition to the expected [2...
A novel series of quinoline‐based symmetrical and unsymmetrical bis‐chalcones was synthesized via a Claisen–Schmidt condensation reaction between 3‐formyl‐quinoline/quinolone derivatives with acetone or arylidene acetones, respectively, by using KOH/MeOH/H2O as a reaction medium. Twelve of the obtained compounds were evaluated for their in vitro cytotoxic activity against 60 different human cancer...