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New 5‐cyano‐6‐oxo‐pyridine‐based sulfonamides (6a–m and 8a–d) were designed and synthesized to potentially inhibit both the epidermal growth factor receptor (EGFR) and carbonic anhydrase (CA), with anticancer properties. First, the in vitro anticancer activity of each target substance was tested using Henrietta Lacks cancer cell line and M.D. anderson metastasis breast cancer cell line cells. Then,...
Lung, colorectal, and breast cancers are the top three types of cancer by incidence and are responsible for one‐third of the cancer incidence and mortality. A series of 18 3,4‐dihydropyrimidine analogues bearing a 1,2‐methylenedioxybenzene component at position 4 with diverse side chains at positions 5 and 6 was designed and synthesized as inhibitors of the Eg5 kinesin enzyme. Target compounds were...
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